Tag

Organoids

All articles tagged with #organoids

science11 days ago•4 min saved

Dancing molecules drive repair in lab-grown human spinal cords

Northwestern researchers grew 3-millimeter-wide human spinal cord organoids from iPSCs, injured them in two ways, and treated them with IKVAV-PA 'dancing' supramolecular peptides that form a scaffold and promote axon regrowth. The treated tissues showed reduced glial scar and inflammation and enhanced neurite growth, aligning with prior mouse data and suggesting potential for human therapies—though clinical use is years away. The work was published in Nature Biomedical Engineering.

via ScienceAlert|

#axon-regeneration #dancing-molecules #glial-scar

science25 days ago•6 min saved

Lab-grown human brain cells steer rat behavior in a first-of-its-kind integration

Scientists transplanted human brain organoids into developing rat embryos, enabling vascularization and functional integration that allowed the human cells to respond to stimuli and influence a rat’s behavior — a breakthrough for human-brain models, but raising ethical questions about consciousness, donor consent, and animal welfare.

via Indian Defence Review|

#brain #ethics #neuroscience

biotechnology26 days ago•11 min saved

Lab-grown liver assembloids edge toward miniaturized human livers

Researchers combine multiple donor liver cell types to form in vitro liver assembloids that recapitulate periportal tissue, moving toward miniature human livers for faster drug testing and personalized therapies.

via Nature|

#bioengineering #biotechnology #in-vitro

science27 days ago•96 min saved

Diverse autism mutations converge on a shared chromatin-regulation network in stem-cell–derived human cortex

A large hiPSC-based study generated cortical organoids from eight ASD-risk mutations, idiopathic ASD, and controls, profiling gene expression across 25–100 days. Early mutation-specific changes give way to convergent transcriptional and chromatin-regulatory disruptions enriched for ASD risk genes, including SWI–SNF components. CRISPRi validation supports key regulators driving this convergent network, suggesting that diverse genetic risks in ASD propagate through shared transcriptional pathways that affect early neurodevelopment, while idiopathic cases show less convergence.

via Nature|

#autism #crispr #ipsc

science1 month ago•4 min saved

Rapid Nasal Interferon Response May Stop Colds Before Symptoms Start

Lab-grown human nasal tissue reveals that an early interferon-driven antiviral defense in nasal cells can stop rhinovirus infection and prevent illness. When this response is fast, the virus is contained with few or no symptoms; if it lags, infection spreads, triggering inflammation and mucus. The findings point to therapies that boost the body's own defenses rather than targeting the virus itself.

via SciTechDaily|

#antiviral-defense #interferon #nasal-epithelium

science2 months ago•113 min saved

Human Assembloids Mimic Periportal Liver Tissue In Vitro

Researchers developed human liver assembloids combining hepatocytes, cholangiocytes, and mesenchyme to mimic periportal liver tissue in vitro, enabling patient-specific disease modeling and functional studies, including fibrosis.

via Nature|

#cell-interactions #human-liver-disease #liver-tissue-models

science2 months ago•5 min saved

Research Reveals Innate Structures in Human Brain Development

Scientists found that human brain circuits produce ordered electrical patterns even before sensory experiences, suggesting that our brains are prewired with internal timing rules for understanding the world, as demonstrated through experiments on brain organoids and neonatal mouse slices.

via Earth.com|

#brain-development #early-neural-activity #neural-circuits

science4 months ago•6 min saved

Embracing Alternatives to Animal Testing for a Sustainable Future

Innovative approaches called NAMs are replacing animal testing in biomedical research, offering more human-relevant, ethical, and cost-effective methods for drug testing and understanding biology. Despite progress and regulatory support, adoption faces resistance, especially in publishing and funding, highlighting the need for systemic change in scientific practices.

via Nature|

#animal-testing-alternatives #drug-development #nams

science4 months ago•2 min saved

Public Shock Over Lab-Grown Human Brains

Scientists have created miniature human brain organoids, sparking ethical debates about whether these lab-grown brains could become conscious and if experimenting on them would be justified, with public opinion divided on the issue.

via Futurism|

#consciousness #ethics #lab-grown-brains

technology4 months ago•5 min saved

Scientists Advance 'Living' Computers and Brain-Cell Communication Technologies

Scientists in Switzerland are developing biocomputers using lab-grown mini-brains called organoids derived from human stem cells, aiming to create energy-efficient, living servers that mimic aspects of AI learning, though challenges like maintaining organoid health and understanding their activity remain.

via BBC|

#ai #biocomputing #human-cells

science5 months ago•8 min saved

Mini Organs Unveil Key Insights into Women's Health

Scientists are developing mini organoids of the placenta, ovaries, and uterine lining to better understand women's reproductive health, addressing limitations of animal models and exploring conditions like pre-eclampsia and endometriosis, with potential to revolutionize diagnosis and treatment.

via Nature|

#endometrium #organoids #placenta

science6 months ago•4 min saved

Advances in Lab-Grown Mini Brains Unveil Brain Development Secrets

Scientists used brain organoids to discover that microglia, the brain's immune cells, produce IGF1 which drives the proliferation of interneurons in the developing human brain, a process potentially unique to humans and important for our cognitive abilities.

via Live Science|

#brain-development #human-evolution #interneurons

science6 months ago•65 min saved

Microglia Influence Prenatal GABAergic Neurogenesis via IGF1

This study reveals that microglia regulate GABAergic interneuron development in the human prenatal brain by secreting IGF1, which promotes progenitor proliferation in the medial ganglionic eminence (MGE). Using human tissue analysis, single-nucleus transcriptomics, and human brain organoid models, the researchers demonstrate a species-specific distribution of microglia and their critical role in interneuron neurogenesis, highlighting potential implications for neurodevelopmental disorders.

via Nature|

#gabaergic-neurogenesis #human-brain-development #igf1

science1 year ago•5 min saved

Breakthrough in Comprehensive Human Cell Mapping Project

Scientists with the Human Cell Atlas project have made significant progress in mapping the 37 trillion cells in the human body, releasing over 40 papers detailing cell profiles from various organs and systems. This research aims to create a comprehensive atlas of human cells, highlighting differences across demographics and genetic backgrounds. The findings include insights into gastrointestinal diseases, early human development, and the creation of organoids, which are lab-grown mini-organs that mimic real organs. This work could lead to breakthroughs in understanding diseases and developing treatments.

via Livescience.com|

#cell-mapping #disease-research #human-cell-atlas

health1 year ago•4 min saved

"Novel Treatment Approaches Unveiled for Polycystic Kidney Disease"

Scientists have made significant progress in understanding and potentially treating polycystic kidney disease (PKD) by using gene editing and 3-D human cell models to study the genetics of the disease. They discovered that a single normal gene copy can prevent the formation of cysts in PKD, offering potential for tailored gene therapy. Additionally, a type of drug called glycoside was found to counteract the effects of the defective gene. These findings could lead to new therapeutic approaches for treating PKD, which affects millions worldwide. The study was partially funded by the National Institutes of Health (NIH) and is published in Cell Stem Cell.

via National Institutes of Health (NIH) (.gov)|

#gene-editing #gene-therapy #health