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Drug Development

All articles tagged with #drug development

China bets big on Alzheimer's with a national research push
science1 day ago

China bets big on Alzheimer's with a national research push

China is launching a sweeping, government-backed effort to prepare for a coming wave of dementia by expanding screening, diagnosis, and treatment, recruiting returning researchers, and funding diverse avenues—from new drugs (including BrAD-R13 and DI-3-n-butylphthalide) to traditional Chinese medicine and novel glymphatic-clearing surgeries. With dementia prevalence expected to rise dramatically, the country aims to reach 2030 targets, accelerate clinical trials (already rising from 9 in 2021 to 107 in 2024), and become a leading global hub—though regulatory safeguards and safety concerns accompany rapid growth.

via Nature|
#alzheimers-disease#china#clinical-trials
FDA Embraces Bayesian Toolkit to Accelerate Drug Trials
health1 month ago

FDA Embraces Bayesian Toolkit to Accelerate Drug Trials

The FDA issued a draft guidance to promote the use of Bayesian methodologies in clinical trials for drugs and biologics, aiming to use prior information and data more efficiently to shorten timelines and reduce costs. The guidance outlines when Bayesian methods can support primary inference and trial design, including early futility/success decisions, dose selection, incorporating external data, enabling subgroup analyses, and aiding rare or pediatric studies; public comment is invited as part of PDUFA VII commitments.

via fda.gov|
#bayesian-methods#clinical-trials#drug-development
New Bone Discovery Paves Way for Exercise-Free Osteoporosis Treatment
health1 month ago

New Bone Discovery Paves Way for Exercise-Free Osteoporosis Treatment

Scientists from HKUMed discovered that the Piezo1 protein acts as an 'exercise sensor' in bones, translating physical activity into signals that strengthen bones and reduce fat accumulation in bone marrow. This breakthrough could lead to the development of drugs that mimic exercise effects, offering new treatments for osteoporosis, especially for those unable to exercise.

via SciTechDaily|
#bone-health#drug-development#exercise-sensor
Vitamin A's Role in Tumor Immune Evasion and New Cancer Treatment Avenues
health-and-science1 month ago

Vitamin A's Role in Tumor Immune Evasion and New Cancer Treatment Avenues

Scientists have discovered that a vitamin A metabolite, retinoic acid, can suppress the immune system's ability to fight cancer by promoting immune tolerance. They developed inhibitors that block this pathway, restoring immune responses and improving cancer vaccine efficacy, paving the way for new immunotherapy treatments.

via SciTechDaily|
#cancer-immunotherapy#dendritic-cells#drug-development
Scientists Find Brain 'Switches' That Clear Alzheimer’s Plaques
health1 month ago

Scientists Find Brain 'Switches' That Clear Alzheimer’s Plaques

Scientists have discovered two brain receptors, SST1 and SST4, that regulate the breakdown of amyloid beta, a protein linked to Alzheimer's disease. Activating these receptors increases neprilysin levels, reduces amyloid plaques, and improves memory in models, suggesting a potential new, safer, and less expensive treatment approach compared to current antibody therapies.

via SciTechDaily|
#alzheimers#amyloid-beta#brain-receptors