Microglia Influence Prenatal GABAergic Neurogenesis via IGF1
Originally Published 5 months ago — by Nature
This study reveals that microglia regulate GABAergic interneuron development in the human prenatal brain by secreting IGF1, which promotes progenitor proliferation in the medial ganglionic eminence (MGE). Using human tissue analysis, single-nucleus transcriptomics, and human brain organoid models, the researchers demonstrate a species-specific distribution of microglia and their critical role in interneuron neurogenesis, highlighting potential implications for neurodevelopmental disorders.