Tag

Human Brain Development

All articles tagged with #human brain development

science5 months ago•65 min saved

Microglia Influence Prenatal GABAergic Neurogenesis via IGF1

This study reveals that microglia regulate GABAergic interneuron development in the human prenatal brain by secreting IGF1, which promotes progenitor proliferation in the medial ganglionic eminence (MGE). Using human tissue analysis, single-nucleus transcriptomics, and human brain organoid models, the researchers demonstrate a species-specific distribution of microglia and their critical role in interneuron neurogenesis, highlighting potential implications for neurodevelopmental disorders.

via Nature|

#gabaergic-neurogenesis #human-brain-development #igf1

neuroscience1 year ago•7 min saved

"Creation of Early Human Central Nervous System Model Using Stem Cells"

Researchers have developed a groundbreaking 3D human organoid system that accurately models the early stages of the human central nervous system (CNS) using patient-derived stem cells, offering new possibilities for studying human brain development and diseases. This comprehensive model simulates the development of the brain and spinal cord, potentially leading to personalized treatment strategies for neurological and neuropsychiatric disorders. The innovation provides a unique platform for understanding the intricacies of the human CNS and its disorders, surpassing the capabilities of previous models.

via Neuroscience News|

#central-nervous-system #human-brain-development #neurological-disorders

science-and-technology1 year ago•89 min saved

Unlocking the Secrets of Human Neuronal Maturation through Epigenetic Manipulation

Researchers have discovered an epigenetic barrier that sets the pace of human neuronal maturation, which is protracted compared to other species. They developed a platform to generate synchronized populations of cortical neurons from human pluripotent stem cells, allowing for the study of neuronal maturation over months in vitro. The study tracked the morphological and functional development of neurons and identified a core set of chromatin regulator genes whose downregulation is associated with neuronal maturation. Loss-of-function studies for these genes induced precocious maturation, suggesting the existence of an epigenetic "brake" that gradually releases to ensure a protracted unfolding of neuronal maturation programs.

via Nature.com|

#epigenetics #human-brain-development #neuronal-maturation

neuroscience2 years ago•3 min saved

Reevaluating Human Brain Development: New Study Challenges Assumptions

A new study challenges the belief that human newborns have significantly less developed brains compared to other primates. The research reveals that human infants are born with brains typical of similar primate species, but their brains grow larger and more complex post-birth, giving the impression of underdevelopment. Contrary to previous notions, this study suggests that humans' brains are in line with those of other primates, including chimpanzees and gorillas, during early development. The findings reshape our understanding of the evolution of human brain development.

via Neuroscience News|

#brain-plasticity #evolution #human-brain-development