Tag

Tumor Microenvironment

All articles tagged with #tumor microenvironment

health-and-medicine9 days ago•6 min saved

Engineered Microbes Target Tumors by Colonizing Oxygen-Starved Cores

Researchers at the University of Waterloo are engineering Clostridium sporogenes bacteria to invade oxygen-poor tumor cores and consume nutrients from inside, potentially destroying tumors. They added an oxygen-tolerance gene and use quorum sensing to activate it only after enough bacteria accumulate, limiting safety risks. Next steps combine both features in a single strain and test in preclinical trials, showcasing interdisciplinary synthetic-biology cancer research.

via ScienceDaily|

#biotechnology #cancer-therapy #health-and-medicine

health-and-medicine17 days ago•5 min saved

Nerve-Fibroblast Loop Spurs Early Pancreatic Cancer Growth

Researchers at Cold Spring Harbor Laboratory uncovered a self-sustaining loop in early pancreatic cancer: myCAFs (fibroblasts) lure sympathetic nerves, whose norepinephrine signals activate the fibroblasts and recruit more nerves, accelerating tumor development. Blocking nerve activity slowed growth by about 50% in mice/human cell experiments, pointing to therapies that disrupt the nerve–fibroblast crosstalk alongside existing cancer treatments.

via ScienceDaily|

#health-and-medicine #mycafs #nervous-system

science24 days ago•7 min saved

Tumor-Modulated Neutrophils Fuel Cancer Growth via CCL3

University of Geneva researchers find that neutrophils recruited to tumors are reprogrammed to produce the chemokine CCL3, which promotes tumor growth. This shift helps explain why some cancers become more aggressive and points to CCL3 activity in neutrophils as a potential prognostic biomarker and therapeutic target. The team used genetic tools to selectively suppress CCL3 in neutrophils and reanalyzed multiple studies to confirm the link.

via SciTechDaily|

#biomarker #cancer-progression #ccl3

science1 month ago•7 min saved

Bacteria-Derived Toxin Halts Colorectal Cancer Growth While Sparing Healthy Tissue

Researchers report that MakA, a toxin from Vibrio cholerae, when delivered systemically, slows colorectal tumor growth in mice by increasing tumor cell death and reshaping the tumor's immune environment, with no observable harm to healthy tissue or organs, suggesting a tumor-targeted anti-cancer strategy that requires further clinical study.

via SciTechDaily|

#bacterial-toxin #cancer-research #colorectal-cancer

science1 month ago•9 min saved

Stellate-Cell Periostin Sparks Early Nerve Invasion in Pancreatic Cancer

Brazilian researchers identify periostin produced by pancreatic stellate cells as a key driver that remodels surrounding tissue, enabling pancreatic cancer cells to invade nerves early and spread, creating a dense desmoplastic microenvironment that hinders chemotherapy and immunotherapy; targeting periostin or the stellate cells offers a potential path for precision therapies to curb invasion and metastasis.

via SciTechDaily|

#pancreatic-cancer #perineural-invasion #periostin

science1 month ago•3 min saved

In-Tumor Therapy Transforms Local Macrophages Into Cancer-Killing Agents

KAIST researchers inject lipid nanoparticles carrying CAR mRNA and immunostimulants directly into tumors to reprogram resident tumor-associated macrophages into anticancer CAR-macrophages, boosting local and potentially systemic anti-tumor immunity and showing strong tumor suppression in animal models.

via SciTechDaily|

#car-macrophages #immunotherapy #in-situ-therapy

cancer-research4 months ago•59 min saved

Key Genetic and Epigenetic Factors Drive Early Bowel Cancer Development

This study explores how epigenetic changes and immune microenvironment interactions drive early immune evasion in colorectal cancer, highlighting chromatin architecture's role in suppressing neoantigen expression and the importance of early immune escape mechanisms in tumor evolution.

via Nature|

#cancer-research #colorectal-cancer #epigenetics

medicine4 months ago•80 min saved

mRNA COVID Vaccines Enhance Cancer Immunotherapy Effectiveness

COVID-19 mRNA vaccines enhance the effectiveness of immune checkpoint inhibitors in cancer treatment by stimulating innate and adaptive immune responses, increasing tumor PD-L1 expression, and potentially restoring immune sensitivity in 'cold' tumors, leading to improved survival outcomes in patients with NSCLC and melanoma.

via Nature|

#cancer-immunotherapy #covid-19-vaccines #immune-checkpoint-blockade

medical-research4 months ago•63 min saved

Mapping Tumor Immune Niches in Diffuse Large B Cell Lymphoma

This study used spatial transcriptomics, proteomics, and genomics to analyze the tumor immune microenvironments in diffuse large B-cell lymphoma (DLBCL), identifying distinct cellular neighborhoods and communication patterns that influence immune cell function and tumor behavior, with implications for targeted immunotherapy.

via Nature|

#dlbcl #ebv #immune-niches

science5 months ago•3 min saved

Physical Stress Triggers Dangerous Changes in Cancer Cells

New research reveals that physical pressure from surrounding tissues can trigger epigenetic changes in cancer cells, making them more invasive and resistant by involving proteins like HMGB2 and structural remodeling, which complicates treatment strategies.

via SciTechDaily|

#cancer #epigenetics #mechanical-stress

cancer-research5 months ago•99 min saved

Small Cell Lung Cancer Exploits Brain Neuronal Synapses to Promote Growth

The article explores how neuronal activity and innervation, particularly via the vagus nerve, influence the initiation, progression, and metastasis of small cell lung cancer (SCLC), highlighting the role of neuron-tumor interactions, synaptic communication, and membrane depolarization in tumor growth within the lung and brain.

via Nature|

#brain-metastasis #cancer-research #neuronal-activity

health7 months ago•3 min saved

Prostate Cancer Converts Immune Cells into Allies of Tumor

Scientists have discovered that certain macrophages in prostate cancer are reprogrammed to support tumor growth and suppress immune responses. Targeting these cells, specifically the SPP1 protein, in mice improved the effectiveness of immunotherapy, offering a potential new approach for treating advanced prostate cancer.

via futurity.org|

#health #immune-cells #immunotherapy

health1 year ago•4 min saved

Cancer Cells' Survival Tactics Against Chemotherapy Uncovered

A study by NYU Langone Health reveals how cancer cells adapt to low-glucose environments, making chemotherapy less effective. The research shows that cancer cells slow down the consumption of uridine nucleotides, crucial for cell growth, in low-glucose conditions, hindering apoptosis. This understanding could lead to improved therapies that manipulate cancer cell responses in such environments. The study highlights the need for new strategies to enhance chemotherapy effectiveness by targeting cancer cell metabolism.

via NYU Langone Health|

#cancer #chemotherapy #health

health2 years ago•2 min saved

"Hydroxyapatite-Targeting Nanodrug Halts Aggressive Breast Cancer Growth"

Researchers at Vanderbilt University have developed a nanoparticle-based drug, NSPS, that targets hydroxyapatite (HAP) in tumor microenvironments, causing localized alkalosis and effectively killing cancer cells in animal models of breast, colon, lung, and prostate cancers. The drug shows limited interaction with normal tissue and bone, making it a potential paradigm-changing approach to cancer treatment, particularly for patients with poor prognosis. Further studies in humans are needed to validate its potential clinical impact.

via Phys.org|

#cancer-treatment #health #hydroxyapatite

health2 years ago•20 min saved

AI: Revolutionizing Cancer Detection and Treatment

A clinical trial testing a new immunotherapy drug on patients with early-stage cancers showed miraculous results, with 100% of patients going into total remission. However, immunotherapy only works for about one in five patients, and doctors currently have no way of predicting which patients will respond. Recent advances in artificial intelligence (AI) and imaging technology are providing researchers with the ability to interpret complex data on tumor microenvironments and genetic makeup, potentially leading to more effective treatments. AI is being used to analyze large datasets and identify patterns that could help develop personalized therapies for individual patients. While there is still much progress to be made, these advancements offer hope for the future of cancer treatment.

via Newsweek|

#artificial-intelligence #cancer-research #clinical-trials