Tag

Biomarker

All articles tagged with #biomarker

health6 days ago•5 min saved

Blood tau clock could forecast when Alzheimer’s symptoms begin

A Nature Medicine study describes a blood test that detects an abnormal form of tau in the blood, which may serve as a molecular clock to predict not only if someone will develop Alzheimer’s but also when symptoms could start. If validated in larger trials, it could enable earlier interventions and streamline clinical testing for therapies, though experts caution that it’s not yet recommended for cognitively unimpaired individuals to use this biomarker outside of research.

via Nature|

#alzheimers-disease #biomarker #blood-test

health6 days ago•15 min saved

Semen analysis as a routine health check for men sparks hype and skepticism

The piece explores the idea that routine semen analysis could serve as a broad biomarker for men’s health—potentially a “new Pap smear” that flags risks for metabolic, cardiovascular, and cancer conditions. Startups are offering mail-in and at-home testing to tap a growing market, while medical experts caution that there is insufficient evidence that broad semen screening improves health outcomes, and warn of logistical, ethical, and equity concerns and possible overdiagnosis.

via statnews.com|

#biomarker #fertility #health

health10 days ago•2 min saved

FDA Rejects Disc Medicine's Porphyria Drug Over Uncertain Biomarker Benefit

The FDA rejected Disc Medicine's bitopertin for porphyria, citing uncertainties that the biomarker used as the efficacy endpoint may not translate to real patient benefit, marking the first setback for a drug in Commissioner Makary's fast-track review program and sending Disc's shares lower.

via statnews.com|

#biomarker #bitopertin #disc-medicine

biotech16 days ago•2 min saved

FDA rejects Regenxbio’s Hunter syndrome gene therapy over biomarker doubts

The FDA has rejected Regenxbio’s RGX-121 gene therapy for mucopolysaccharidosis type II (Hunter syndrome), citing concerns about the surrogate cerebrospinal fluid biomarker used to predict longer-term cognitive benefit and casting doubt on the accelerated-approval pathway.

via statnews.com|

#biomarker #biotech #fda

science16 days ago•7 min saved

Tumor-Modulated Neutrophils Fuel Cancer Growth via CCL3

University of Geneva researchers find that neutrophils recruited to tumors are reprogrammed to produce the chemokine CCL3, which promotes tumor growth. This shift helps explain why some cancers become more aggressive and points to CCL3 activity in neutrophils as a potential prognostic biomarker and therapeutic target. The team used genetic tools to selectively suppress CCL3 in neutrophils and reanalyzed multiple studies to confirm the link.

via SciTechDaily|

#biomarker #cancer-progression #ccl3

science26 days ago•5 min saved

Brainwave marker pinpoints moment consciousness fades under anesthesia

A study with 31 participants under propofol anesthesia identifies a distinctive brain-wave pattern and decreasing inter-regional connectivity—especially between the parietal cortex and thalamus and between parietal and occipital areas—that mark loss of consciousness, suggesting an actionable biomarker to refine dosing, though findings are limited to one anesthetic and rely on new methods to infer whole-brain signals from scalp data.

via Nature|

#anesthesia #biomarker #brain-waves

science1 month ago•3 min saved

Resting Beta-Wave Signatures Could Foresee Alzheimer's Years Earlier

A Brown University-led study using noninvasive magnetoencephalography (MEG) tracked resting brain activity in 85 individuals with mild cognitive impairment and found that those who later developed Alzheimer's showed beta-wave bursts that were shorter, weaker, and less frequent, suggesting a potential early biomarker for progression up to about 2.5 years before diagnosis.

via ScienceAlert|

#alzheimers-disease #beta-waves #biomarker

health2 months ago•4 min saved

AI Uncovers Hidden Stress Indicators in Routine CT Scans

Researchers used AI to identify a new biomarker of chronic stress visible on standard CT scans by measuring adrenal gland size, which correlates with stress levels and predicts cardiovascular risk, offering a practical tool for assessing long-term stress effects in clinical settings.

via ScienceDaily|

#adrenal-glands #ai #biomarker

health4 months ago•5 min saved

Scientists Uncover Brain Mechanism Behind Hearing Voices in Schizophrenia

A study from UNSW Sydney provides strong evidence that hearing voices in schizophrenia may be due to the brain's failure to recognize its own inner speech, with potential implications for early diagnosis and treatment of psychosis.

via SciTechDaily|

#auditory-hallucinations #biomarker #brain-activity

health4 months ago•3 min saved

Scientists develop first accurate blood test for chronic fatigue syndrome

Scientists in the UK have developed a blood test analyzing epigenetic changes in immune cells that could potentially diagnose chronic fatigue syndrome (ME/CFS), offering hope for earlier and more accurate diagnosis, though further research is needed due to the small study size.

via Nature|

#biomarker #blood-test #chronic-fatigue-syndrome

health5 months ago•5 min saved

Early Detection and Prevention of Alzheimer’s Through New Biomarkers and Protein Targets

Scientists have identified that the protein TSPO, indicating brain inflammation, appears in specific brain regions at the same time as early amyloid-beta plaque formation in Alzheimer's disease, potentially enabling earlier diagnosis and intervention, with findings confirmed in both mouse models and human tissue.

via PsyPost|

#alzheimers #biomarker #brain-inflammation

health5 months ago•4 min saved

Scientists Discover MicroRNA That Protects Kidneys in Breakthrough Study

Canadian researchers have discovered a microRNA, miR-423-5p, that can protect kidney blood vessels after injury and serve as a blood-based biomarker for early detection and treatment of chronic kidney disease, with potential applications in transplantation and other vascular-related conditions.

via SciTechDaily|

#biomarker #chronic-kidney-disease #health

health6 months ago•6 min saved

Eye Exams May Detect Alzheimer’s Risk Years in Advance

Research suggests that routine eye exams could detect early signs of Alzheimer's disease by identifying abnormal retinal blood vessel changes linked to genetic risk factors, potentially decades before symptoms appear, highlighting the retina's role as a window into brain health.

via Neuroscience News|

#alzheimers #biomarker #early-diagnosis

science7 months ago•3 min saved

Shared Trait Found in Newborns and Alzheimer’s Patients

A recent study reveals that both newborns and Alzheimer's patients have elevated levels of the brain protein p-tau217, which plays different roles in each group—supporting healthy brain development in infants and indicating neurodegeneration in Alzheimer's. The findings suggest that understanding how the healthy brain manages tau could lead to new treatments for Alzheimer's disease.

via SciTechDaily|

#alzheimers #biomarker #brain-development

environment7 months ago•4 min saved

Parasitic Worm Could Boost Chesapeake Bay Blue Crab Populations

A study suggests that a parasitic, egg-eating worm found on female blue crabs in Chesapeake Bay could serve as a biomarker for their reproductive history, helping to manage and potentially rebuild crab populations by identifying spawning females and understanding reproductive patterns, especially in low-salinity conditions.

via Phys.org|

#biomarker #blue-crabs #chesapeake-bay