Nerve-Fibroblast Loop Spurs Early Pancreatic Cancer Growth
TL;DR Summary
Researchers at Cold Spring Harbor Laboratory uncovered a self-sustaining loop in early pancreatic cancer: myCAFs (fibroblasts) lure sympathetic nerves, whose norepinephrine signals activate the fibroblasts and recruit more nerves, accelerating tumor development. Blocking nerve activity slowed growth by about 50% in mice/human cell experiments, pointing to therapies that disrupt the nerve–fibroblast crosstalk alongside existing cancer treatments.
Topics:health#health-and-medicine#mycafs#nervous-system#norepinephrine#pancreatic-cancer#tumor-microenvironment
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- Científicos encuentran nervios activamente alimentan el cáncer de páncreas surfcoastnews.com.au
- Taking Aim at Pancreatic Cancer’s Nerve Connections BIOENGINEER.ORG
- Early nerve–fibroblast crosstalk drives pancreatic cancer development: study Labmate Online
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