tldrdaily.news logo
Tag

Epigenetics

All articles tagged with #epigenetics

Fungicide Exposure Echoes through 20 Rat Generations via Epigenetic Inheritance
science4 days ago

Fungicide Exposure Echoes through 20 Rat Generations via Epigenetic Inheritance

A Washington State University study in rats shows that a single in-utero exposure to the fungicide vinclozolin can imprint disease risk that persists for 20 generations, with birth-related mortality rising in later generations. The inherited effects are germline-based epigenetic changes, suggesting long-term implications for human disease and highlighting the potential for epigenetic biomarkers to enable preventative medicine decades before disease onset.

via Neuroscience News|
#biomarkers#epigenetics#science
AI-driven blood test uses epigenetic fingerprints to flag high-risk prediabetes
health7 days ago

AI-driven blood test uses epigenetic fingerprints to flag high-risk prediabetes

A German study shows that an AI-enhanced blood test analyzing DNA methylation markers can classify people into high- or moderate-risk prediabetes groups with about 90% accuracy, using 1,557 epigenetic markers to form a biological fingerprint. This approach could enable earlier, personalized prevention and reduce progression to type 2 diabetes, potentially serving as a simpler, cost-effective diagnostic tool compared with extensive clinical testing.

via Medical News Today|
#artificial-intelligence#biomarkers#diabetes-prevention
Worrying About Aging Could Speed Up Your Biological Clock
health7 days ago

Worrying About Aging Could Speed Up Your Biological Clock

A study of 726 women found that higher anxiety about aging—especially fears of declining health—was linked to faster epigenetic aging (via DunedinPACE and GrimAge clocks), suggesting health worries may biologically accelerate aging, though causation isn’t proven. Experts note that chronic worry can trigger stress responses, inflammation, and sleep disruption, and advise focusing on present health, differentiating one’s health from others, and seeking mental-health support if anxiety disrupts daily life.

via SELF Magazine|
#aging#epigenetics#health
Itaconate fuels ZFTA–RELA+ ependymoma by epigenetically sustaining its driver
science19 days ago

Itaconate fuels ZFTA–RELA+ ependymoma by epigenetically sustaining its driver

A Nature study shows ZFTA–RELA+ ependymomas produce itaconate via ACOD1, fueling a feed-forward loop that epigenetically maintains ZFTA–RELA expression by increasing activating H3K4me3 through inhibition of the KDM5 demethylase. The tumors also upregulate glutamine metabolism to supply itaconate precursors. Blocking ACOD1 or glutamine metabolism reduces pathogenic ZFTA–RELA levels and inhibits tumor growth in cell and animal models, with combination approaches (glutamine antagonism plus PI3K–mTOR inhibition) suppressing spinal metastasis. The findings position itaconate as a potential therapeutic vulnerability in ZFTA–RELA+ ependymomas and highlight oncometabolites as treatment targets.

via Nature|
#acod1#ependymoma#epigenetics
Transient HDAC inhibition imprints lasting gene and genome architecture memory in stem cells
science20 days ago

Transient HDAC inhibition imprints lasting gene and genome architecture memory in stem cells

A four-hour pulse of the HDAC inhibitor TSA in mouse embryonic stem cells transiently boosts H3K27ac and shifts transcription from pluripotency toward development; genome folding also rewires with more interchromosomal contacts and weaker A-compartment interactions. Most changes reverse after washout, but a subset of genes remains misregulated and the 3D genome stays perturbed, constituting a memory that is strengthened by a second TSA pulse and linked to Polycomb-mediated looping. Disrupting canonical PRC1 (PCGF2/PCGF4) reduces this memory, indicating Polycomb topology contributes to transcriptional memory.

via Nature|
#3d-genome#embryonic-stem-cells#epigenetics
Genetics and environment jointly sculpt the immune cell epigenome
science29 days ago

Genetics and environment jointly sculpt the immune cell epigenome

Single-cell methylome and chromatin-accessibility analysis across 171 PBMC samples shows that genetic variation and environmental exposures independently shape immune cell epigenomes, with exposure- and genotype-associated regions showing distinct genomic enrichments (eDMRs at enhancers, gDMRs in gene bodies); colocalization of meQTLs with disease GWAS signals provides cell-type-specific insights into how genetics and environment influence health and disease.

via Nature|
#edmr#epigenetics#gdmr
Aging-Driven Epigenetic Drift in Gut Stem Cells May Raise Colorectal Cancer Risk
science1 month ago

Aging-Driven Epigenetic Drift in Gut Stem Cells May Raise Colorectal Cancer Risk

Researchers identify ACCA drift—an age-related epigenetic shift in intestinal crypt stem cells driven by inflammation, reduced growth signaling, and iron deficiency that silences tumor-suppressor genes. As crypts divide, these altered regions expand, creating healthier but cancer-prone areas across the gut and potentially increasing colorectal cancer risk with age. Studies in human tissue, mice, and organoids also show the drift can be slowed or partly reversed by boosting iron uptake or restoring growth signals.

via ScienceAlert|
#aging#colorectalcancer#epigenetics
Winter's Hidden Role in Earth's Survival
science1 month ago

Winter's Hidden Role in Earth's Survival

The article discusses how the decline in winter cold and frost days due to climate change disrupts key biological processes in plants and pests, affecting agriculture and ecosystems. Cold is essential for plant vernalization, pest control, and ecological balance, but warming winters threaten these functions, leading to potential crop failures and ecological shifts. Scientists are exploring ways to mimic or stabilize cold responses in plants through genetic and epigenetic techniques to adapt to a changing climate.

via The Daily Galaxy|
#agriculture#climate-change#cold-temperatures