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Cancer Immunotherapy

All articles tagged with #cancer immunotherapy

Pill-Based Donor Microbes Show Early Promise in Boosting Cancer Immunotherapy
health26 days ago

Pill-Based Donor Microbes Show Early Promise in Boosting Cancer Immunotherapy

Two small Nature Medicine trials suggest oral fecal microbiota transplantation (FMT) pills may boost immunotherapy in advanced cancers: in metastatic kidney cancer, FMT reduced immunotherapy side effects and produced about a 50% response; in advanced lung cancer or melanoma, combining FMT with immunotherapy yielded response rates around 75–80%, higher than typical 39–45% rates. While promising, results are early and require larger trials.

via Gizmodo|
#cancer-immunotherapy#fecal-microbiota-transplantation#health
Statins May Boost Immunotherapy by Blocking Cancer PD-L1 Cargo
health-and-medicine28 days ago

Statins May Boost Immunotherapy by Blocking Cancer PD-L1 Cargo

Researchers found that cancer cells load the immune-inhibiting protein PD-L1 into tiny extracellular vesicles via the protein UBL3, helping tumors suppress immune responses. Statins block this UBL3-driven modification, reducing PD-L1 cargo and potentially improving responses to immune checkpoint inhibitors, with supporting evidence from non-small cell lung cancer patients showing fewer PD-L1–containing vesicles in those taking statins.

via ScienceDaily|
#cancer-immunotherapy#extracellular-vesicles#health-and-medicine
KLHL6 tunes T cell fate to boost cancer immunotherapy
cancer-immunotherapy1 month ago

KLHL6 tunes T cell fate to boost cancer immunotherapy

A Nature study identifies the E3 ubiquitin ligase KLHL6 as a dual regulator of CD8+ T cell exhaustion and mitochondrial fitness. KLHL6 promotes TOX poly-ubiquitination and degradation, delaying terminal exhaustion, while also restraining excessive mitochondrial fission via the PGAM5–Drp1 axis to maintain T cell metabolism. TCR stimulation downregulates KLHL6, but enforced KLHL6 expression in adoptively transferred T cells enhances anti-tumor and anti-viral responses, highlighting KLHL6 as a clinically actionable target to improve cancer immunotherapy by tuning proteostasis.

via Nature|
#cancer-immunotherapy#klhl6#mitochondrial-dynamics
Vitamin A's Role in Tumor Immune Evasion and New Cancer Treatment Avenues
health-and-science1 month ago

Vitamin A's Role in Tumor Immune Evasion and New Cancer Treatment Avenues

Scientists have discovered that a vitamin A metabolite, retinoic acid, can suppress the immune system's ability to fight cancer by promoting immune tolerance. They developed inhibitors that block this pathway, restoring immune responses and improving cancer vaccine efficacy, paving the way for new immunotherapy treatments.

via SciTechDaily|
#cancer-immunotherapy#dendritic-cells#drug-development
mRNA COVID-19 vaccines show promise in enhancing cancer treatment and survival
health4 months ago

mRNA COVID-19 vaccines show promise in enhancing cancer treatment and survival

A study finds that COVID-19 mRNA vaccines, like Pfizer and Moderna, can boost the immune system to recognize and kill cancer cells, especially when combined with immunotherapy, potentially extending benefits to more cancer patients. The vaccines act as an immune alarm, helping to turn 'cold' tumors 'hot,' and are being tested in clinical trials for lung cancer.

via Live Science|
#cancer-immunotherapy#clinical-trial#covid-19-vaccines
Mitochondria and lysosomes reprogram immune cells to reduce inflammation
science4 months ago

Mitochondria and lysosomes reprogram immune cells to reduce inflammation

Scientists at St. Jude's Research Hospital discovered how mitochondria and lysosomes work together to activate and deactivate regulatory T cells, which are crucial for controlling inflammation and immune responses. Their findings reveal metabolic and organelle signaling pathways that influence T cell function, with potential implications for treating autoimmune diseases and enhancing cancer immunotherapy.

via Medical Xpress|
#cancer-immunotherapy#immune-regulation#lysosomes
mRNA COVID vaccines show promise in enhancing cancer treatment and survival
health4 months ago

mRNA COVID vaccines show promise in enhancing cancer treatment and survival

A study presented at the 2025 European Society for Medical Oncology Congress suggests that COVID-19 mRNA vaccines may enhance survival in patients with advanced lung and melanoma cancers by sensitizing tumors to immunotherapy, nearly doubling median survival times when administered within 100 days of starting immune checkpoint inhibitors.

via CIDRAP|
#cancer-immunotherapy#covid-19-vaccines#health
Proteotoxic Stress and Protein Misfolding Drive T Cell Exhaustion and Immune Evasion
health4 months ago

Proteotoxic Stress and Protein Misfolding Drive T Cell Exhaustion and Immune Evasion

The study reveals that proteotoxic stress response (PSR) drives T cell exhaustion in cancer, characterized by increased protein synthesis, chaperone activation, and protein aggregation, with sustained AKT activity as a key upstream driver. Targeting specific chaperones like gp96 and BiP can mitigate exhaustion and improve immunotherapy outcomes.

via Nature|
#akt-signalling#cancer-immunotherapy#health
Cancer-Induced Nerve Damage and Inflammation Drive Immunotherapy Resistance
cancer-research6 months ago

Cancer-Induced Nerve Damage and Inflammation Drive Immunotherapy Resistance

Cancer-induced nerve injury (CINI) promotes resistance to anti-PD-1 therapy by causing myelin degradation and chronic inflammation, which leads to immune exhaustion. The study shows that nerve injury within tumors correlates with immunosuppressive activity and therapy resistance across multiple cancer types, and that blocking nerve injury signaling can improve immune response and treatment efficacy.

via Nature|
#anti-pd-1-resistance#cancer-immunotherapy#cancer-research