medical-research16.2 min read
Gut Microbes and Auto-Brewery Syndrome: Understanding Self-Produced Alcohol
3 days ago•Source: Nature
Medical Research News
The latest medical research stories, summarized by AI
Featured Medical Research Stories
View original source
28.25 min•2 months ago
Bioinformatics Accelerates Development of Regenerative Therapies for Spinal Cord Injury
Researchers identified thiorphan as a promising drug to promote neural regeneration and functional recovery after spinal cord injury by using a bioinformatics-driven pipeline, in vitro and in vivo testing, and validation in primate and human neurons, showing its potential for clinical translation.
57.95 min•2 months ago
Implant-Based Slow Release of Molecules to Prevent Glioblastoma Recurrence
More Medical Research Stories
Scientists Develop Drug to Counteract Cancer-Related Wasting
Originally Published 3 months ago — by Nature
Research identifies RNA expression patterns linked to cachexia, a severe weight-loss syndrome associated with cancer that involves skeletal muscle wasting and is resistant to nutritional interventions, potentially leading to new treatment targets.
Scientists Achieve First Human Transplant Using Enzyme-Converted Universal Donor Kidney
Originally Published 3 months ago — by Nature
Researchers successfully converted a donor kidney's blood type from A to O using an enzyme, enabling its transplantation into a recipient, which could significantly improve organ donation accessibility and reduce wait times.
Innovative Methods Unveil Cancer Evolution and Resistance in Ovarian Cancer
Originally Published 3 months ago — by Nature
The study introduces CloneSeq-SV, a method combining single-cell whole-genome sequencing and circulating tumor DNA analysis to track clonal evolution and structural variants in ovarian cancer, revealing mechanisms of drug resistance and potential for adaptive therapy.
Autoimmune Mechanisms in ALS Reveal New Disease Insights
Originally Published 3 months ago — by Nature
The study identifies C9orf72 as a major autoantigen targeted by CD4+ T cells in ALS patients, with responses skewed towards an anti-inflammatory profile, especially in those with longer survival, suggesting a potential protective immune component in ALS progression.
Emerging Role of GLP-1 Receptor Agonists in Bipolar Disorder Treatment
Originally Published 4 months ago — by Nature
This review explores the potential of glucagon-like peptide-1 (GLP-1) receptor agonists as emerging treatments for bipolar disorder, summarizing preclinical and clinical evidence supporting their therapeutic role in mood regulation, neuroprotection, and metabolic health.
Missing Enzyme-Rescue Metabolite Causes Rare Skeletal Dysplasia
Originally Published 4 months ago — by Nature
The study identifies TGDS as an enzyme producing UDP-4-keto-6-deoxyglucose, which reactivates UXS1, a key enzyme in glycosaminoglycan synthesis. Deficiency in TGDS impairs this process, leading to Catel–Manzke syndrome, a rare skeletal disorder, with evidence from cell models, patient fibroblasts, and mouse models supporting this molecular mechanism.
Nighttime Pistachios Improve Gut Bacteria in Prediabetic Adults
Originally Published 6 months ago — by News-Medical
A study found that consuming pistachios at night for 12 weeks alters gut bacteria in adults with prediabetes, increasing beneficial bacteria like Roseburia and Lachnospiraceae, which may support gut health and potentially slow the progression to Type 2 diabetes, though further research is needed to confirm health benefits.
MIT's Hydrogel 'Invisibility Cloak' Prevents Implant Scarring
Originally Published 1 year ago — by MIT News
MIT engineers have developed a hydrogel adhesive coating for medical implants that prevents fibrosis, or scar tissue formation, which can interfere with device function. This adhesive binds the devices to tissue, preventing the immune system from attacking them. The approach has shown success in animal models and could be used for various implants, including pacemakers and drug delivery devices. The research, published in Nature, was funded by the NIH and NSF.
"Preventing Brain Injuries: Strategies to Avoid Neurosurgery Consultations"
Originally Published 1 year ago — by First10EM
A prospective multi-institutional trial validated the Brain Injury Guidelines (BIG) for traumatic brain injury patients, finding that low-risk patients classified by BIG did not require neurosurgical intervention, potentially reducing resource utilization. However, the study's data has limitations, including missing information and loss to follow-up, and lacks statistical analysis, suggesting caution in complete guideline implementation. The study highlights the need for further research and consideration of selection bias and generalizability in applying the guidelines to diverse clinical settings.
New Fusobacterium Nucleatum Clade Found in 50% of Aggressive Colon Cancers
Originally Published 1 year ago — by Nature.com
A study reveals that a specific clade within the Fusobacterium nucleatum (Fn) subspecies dominates the colorectal cancer (CRC) niche, with in vitro and in vivo studies demonstrating its high virulence in the context of CRC. Comparative genomics and functional studies show that this clade, known as Fna clade 2 (Fna C2), is significantly associated with the CRC niche and possesses distinct genetic and epigenetic characteristics compared to Fna clade 1 (Fna C1). Fna C2 is enriched in CRC tumors and exhibits differential invasion potential and morphological differences compared to Fna C1, shedding light on its potential role in CRC pathogenicity.