All articles tagged with #bacterial toxin
Researchers report that MakA, a toxin from Vibrio cholerae, when delivered systemically, slows colorectal tumor growth in mice by increasing tumor cell death and reshaping the tumor's immune environment, with no observable harm to healthy tissue or organs, suggesting a tumor-targeted anti-cancer strategy that requires further clinical study.
Researchers at Tel Aviv University have successfully encoded a bacterial toxin into mRNA molecules and delivered them directly to cancer cells, causing the cells to produce the toxin and ultimately leading to their death. The study achieved a success rate of 50% in killing cancer cells. By using lipid nanoparticles coated with antibodies, the researchers ensured that the instructions for producing the toxin reached the target cancer cells. This approach offers a selective and potentially more effective treatment for cancer, as it avoids harming healthy cells and may prevent the development of resistance.
Researchers at Tel Aviv University have successfully induced cancer cell suicide in animals with melanoma by delivering mRNA molecules encoding a bacterial toxin directly to the tumor bed. The nanoparticles carrying the mRNA were injected into the tumors, causing the cancer cells to produce the toxic protein that eventually killed them. This groundbreaking study achieved a success rate of 44% to 60% in eliminating cancer cells without harming healthy cells. The researchers believe this method could be applied to various types of cancer using different natural toxins, offering a promising alternative to chemotherapy.