In-Tumor Therapy Transforms Local Macrophages Into Cancer-Killing Agents
TL;DR Summary
KAIST researchers inject lipid nanoparticles carrying CAR mRNA and immunostimulants directly into tumors to reprogram resident tumor-associated macrophages into anticancer CAR-macrophages, boosting local and potentially systemic anti-tumor immunity and showing strong tumor suppression in animal models.
Topics:health#car-macrophages#immunotherapy#in-situ-therapy#lipid-nanoparticles#science#tumor-microenvironment
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