All articles tagged with #mouse model
A Tulane study using a mouse model found that while both COVID-19 and influenza can cause lasting lung injury, only SARS-CoV-2 infection led to persistent brain inflammation and microvascular damage after the virus was no longer detectable, helping explain long-COVID brain symptoms and highlighting distinct brain-attack mechanisms from flu; findings could inform post-infection monitoring and treatment.
Stanford Medicine researchers report an intranasal vaccine that activates innate and adaptive immunity to provide months-long protection in mice against a broad spectrum of respiratory threats—SARS-CoV-2 and other coronaviruses, Staphylococcus aureus, Acinetobacter baumannii, and house dust mite allergen—suggesting a path toward a universal respiratory vaccine, with human safety trials planned next.
Scientists at the University of Kentucky developed a mouse model that can switch the APOE gene from a high-risk to a protective form in adults, leading to improvements in Alzheimer’s disease markers and cognitive function, highlighting potential gene-based therapies for the future.
Scientists discovered that blocking the TAK1 protein in cancer cells slows tumor growth and enhances immune system attack in mice, suggesting a potential target for improving cancer immunotherapy, especially for melanoma, though further research is needed for human application.
A study from Texas Tech found that the blood-brain barrier remains largely intact in a common mouse model of Alzheimer's, challenging previous beliefs that the disease causes widespread BBB leakiness, which has implications for drug delivery strategies.
Stanford scientists discovered that hyperactivity in the reticular thalamic nucleus may drive autism symptoms in mice, and suppressing this activity with drugs reversed behaviors associated with autism, suggesting a new treatment target.
The article introduces spatial-DMT, a novel technology for simultaneous spatial profiling of DNA methylome and transcriptome in tissue sections at near single-cell resolution, applied to mouse embryos and brains, revealing intricate gene regulation mechanisms during development and tissue-specific epigenetic landscapes.
Researchers from Harvard Medical School discovered that lithium levels in the brain are linked to Alzheimer's disease, and that supplementing with lithium can reverse memory loss in mice, suggesting potential new avenues for treatment and early diagnosis in humans.
A study found that noninvasive spinal stimulation using Multipath DCS extended survival and reduced disease markers in ALS mice, supporting its potential for human treatment, with ongoing clinical trials testing its safety and efficacy.
A study in mice suggests that cannabidiol (CBD) may improve memory and reduce brain plaques associated with Alzheimer's by calming overactive neurons through glycine receptors, highlighting its potential as a therapeutic option, though further research is needed.
Researchers at Osaka Metropolitan University have developed the Mouse Aging Proteomic Atlas, a comprehensive database mapping protein changes in major tissues of aging mice. This atlas reveals proteins linked to aging, particularly in the extracellular matrix, enhancing our understanding of molecular aging and identifying potential targets for preventing age-related diseases. The study provides valuable insights into age-related post-transcriptional dysregulation and its impact on protein expression across different tissues.
Researchers at Michigan State University have developed a new genetic model to study breast cancer, focusing on the E2F5 gene's role in tumor development and metastasis. This model, which uses genetically engineered mice, offers insights into how breast cancer spreads to organs like the liver and bones, rather than just the lungs, making it more relevant to human cases. The research aims to identify specific genes regulated by E2F5 that drive cancer progression, potentially leading to targeted therapies with fewer side effects in the future.
Two specific strains of fungi, Cyberlindnera jadinii and Kluyveromyces lactis, commonly used in food production, have shown positive probiotic effects on gut inflammation in a mouse model. The study, published in mSystems, highlights the potential of these fungi in treating inflammatory bowel disease (IBD), such as ulcerative colitis and Crohn's disease. However, further research is needed before applying these findings to human clinical settings. Probiotics, including bacterial strains, are known to support gut health, and while the role of fungi in gut microbiome is understudied, this research opens up new possibilities for understanding the impact of fungi on gut health.
A new study reports that a treatment called low-field magnetic stimulation (LFMS), which uses weak magnetic waves to stimulate the brain, effectively eased symptoms in a mouse model of Parkinson's disease. LFMS has previously shown promise in improving motor and cognitive functions in brain injury models. The researchers hope to conduct a small-scale study in humans to further test the technology's effectiveness. LFMS has the potential to be a complementary treatment that can be used at home by patients themselves.
A study from the University of California San Diego School of Medicine has shown that time-restricted feeding, a form of intermittent fasting, can improve circadian disruptions and Alzheimer's pathology in a mouse model. Mice fed on a time-restricted schedule exhibited improved memory, reduced accumulation of amyloid proteins in the brain, and better cognitive performance. The findings suggest that targeting circadian disruptions could be a promising approach for Alzheimer's treatment, and the researchers anticipate conducting human clinical trials. Time-restricted feeding offers a potential lifestyle change that could significantly benefit individuals with Alzheimer's disease and their caregivers.