A recent study in mice suggests that restoring NAD+ levels with the compound P7C3-A20 can reverse brain damage and cognitive decline associated with advanced Alzheimer's disease, challenging the notion that the disease is irreversible. The findings highlight the potential for treatments targeting brain energy balance to repair damage and improve function, though further research in humans is needed.
Researchers suggest that targeting the Apoe gene, particularly its harmful variants Apoe3 and Apoe4, could potentially prevent most cases of Alzheimer's disease, although challenges remain due to the gene's vital functions and widespread presence in the population.
A revolutionary breakthrough could soon enable testing for Alzheimer's disease through a simple finger prick, potentially allowing for earlier diagnosis and treatment.
Scientists have successfully reversed Alzheimer's symptoms in mice using a compound called P7C3-A20 that restores NAD+ levels, suggesting potential for human treatment and challenging the belief that brain damage from Alzheimer's is irreversible.
Scientists at the University of Kentucky developed a mouse model that can switch the APOE gene from a high-risk to a protective form in adults, leading to improvements in Alzheimer’s disease markers and cognitive function, highlighting potential gene-based therapies for the future.
Israeli scientists discovered that brain cells may spread toxic proteins linked to Alzheimer's by expelling them into surrounding tissue, potentially accelerating disease progression, with implications for early diagnosis and targeted treatments.
Researchers have identified over 150 DNA control signals in brain cells called astrocytes that may influence Alzheimer's disease, using CRISPRi to study enhancer regions in non-coding DNA, which could lead to new insights and potential treatments for the disease.
Scientists have discovered that restoring the brain's energy molecule NAD+ can prevent and reverse Alzheimer's damage in animal models, suggesting a potential new approach for treatment and recovery in humans.
Scientists from NTU Singapore discovered that enlarged perivascular spaces, which block the brain's waste removal system, may serve as early indicators of Alzheimer's disease, especially in Asian populations, and can be identified through routine MRI scans, potentially enabling earlier diagnosis and intervention.
Scientists at Brown University have identified specific patterns in brain electrical activity, particularly in the beta frequency band, that can predict the development of Alzheimer's disease up to two and a half years before diagnosis, using a novel analytical approach called the Spectral Events Toolbox applied to magnetoencephalography data.
A 19-year-old in China was diagnosed with Alzheimer's disease, making him the youngest known case without any genetic mutations typically associated with early-onset Alzheimer's, highlighting the disease's complex and not fully understood nature.
Neuroscientists warn that microplastics may contribute to neurodegenerative diseases like Alzheimer's by disrupting cellular pathways in the brain, emphasizing the need for reduced plastic use and better environmental policies to protect human health.
A large study of African American brains has identified the ADAMTS2 gene as significantly linked to Alzheimer's disease, with higher activity levels observed in affected individuals, suggesting a shared biological pathway across populations and potential for targeted therapies.
Delays in diagnosing dementia in Michigan lead to missed opportunities for treatment, planning, and support, with experts emphasizing the importance of early detection for access to new drugs, lifestyle changes, and better quality of life. Barriers include stigma, lack of awareness, and specialist shortages, but early diagnosis can significantly improve outcomes and allow families to plan for the future.
A new study shows that the drug candidate P7C3-A20 can restore cognitive functions, reduce brain damage, and repair the blood-brain barrier in mice with advanced Alzheimer's, suggesting potential for future human treatments by restoring NAD+ levels, though more research is needed.
