All articles tagged with #brain inflammation
A study suggests that an X-linked gene called KDM6A, which is more active in women, may contribute to higher rates of multiple sclerosis in women by promoting brain inflammation. Deleting this gene in female mice reduced symptoms, and the drug metformin showed potential in calming inflammation, indicating sex-specific treatment possibilities.
Scientists have identified that the protein TSPO, indicating brain inflammation, appears in specific brain regions at the same time as early amyloid-beta plaque formation in Alzheimer's disease, potentially enabling earlier diagnosis and intervention, with findings confirmed in both mouse models and human tissue.
Recent studies suggest that gum disease bacteria, specifically P. gingivalis, may play a role in the development of Alzheimer's disease by infecting the brain and promoting amyloid beta production, with some evidence indicating this infection could be an early event in the disease process.
A study shows that chronic stress causes immune cells called neutrophils to leave skull bone marrow and gather in the brain's membranes, contributing to depression symptoms. Blocking an immune pathway reduced these cells and improved mood in mice, suggesting new immune-targeted treatments for depression, especially for those unresponsive to current drugs.
A rare genetic disorder called complement factor I deficiency, which is more common in the Amish community due to the founder effect, was identified as the cause of brain inflammation in an Amish girl at CHOP, leading to better diagnosis and treatment for similar cases in the community.
Recent research suggests a potential link between the human pegivirus (HPgV) and Parkinson's disease, with the virus found in the brains of some patients. While the study does not establish causation, it highlights the possible role of viral infections in triggering neurodegenerative processes, adding to the understanding of Parkinson's complex causes. Further research is needed to confirm this connection.
Research suggests that okra may help protect against weight gain by reducing brain inflammation and improving metabolic health, based on a recent rat study. While promising, human trials are needed to confirm these benefits.
Recent studies suggest that COVID-19 may cause lasting brain inflammation, increasing the risk of Alzheimer's disease by promoting cytokine production and amyloid plaque buildup, especially in susceptible populations.
A study in rats suggests that adding okra to the diet can prevent long-term metabolic problems and brain inflammation caused by early-life overfeeding, highlighting okra's potential as a dietary intervention to combat obesity and related disorders.
Scientists have developed diAcCA, a stable drug derived from rosemary's carnosic acid, which shows promise in treating Alzheimer's by reducing brain inflammation and oxidative stress, improving memory, and decreasing disease biomarkers in mouse studies, with potential for human trials due to its safety profile and targeted activation.
A study from 1997 suggests a potential link between herpes simplex virus 1 (HSV-1), common in childhood, and the development of Alzheimer's disease, especially in individuals with the ApoE-e4 gene. While most people with HSV-1 do not develop Alzheimer's, the virus's ability to infect the brain and cause inflammation may contribute to the disease in genetically predisposed individuals. More research is needed to confirm this connection and explore preventive strategies.
A study from 1997 suggests a potential link between herpes simplex virus 1 (HSV-1), common in childhood, and the development of Alzheimer's disease, especially in individuals with the ApoE-e4 gene. While most people with HSV-1 do not develop Alzheimer's, the virus's ability to infect the brain and cause inflammation may increase risk in genetically predisposed individuals. More research is needed to confirm this connection and explore preventive strategies.
Wildfire smoke, which can travel over 1,000 kilometers, poses significant health risks including respiratory issues, heart problems, and potential impacts on brain health such as inflammation and cognitive decline. Vulnerable groups like children, the elderly, and those with pre-existing conditions should take precautions like staying indoors, using masks, and monitoring air quality.
A study from UVA reveals that the immune molecule STING, which becomes hyperactive with age, contributes to Alzheimer's disease by promoting harmful brain inflammation. Blocking STING in mice prevented plaque buildup, protected neurons, and improved memory, suggesting it as a promising therapeutic target for Alzheimer's and other neurodegenerative diseases.
A mouse study found that low vitamin K intake reduces brain vitamin K levels, impairs learning and memory, decreases neurogenesis in the hippocampus, and increases neural inflammation, suggesting vitamin K's importance for cognitive health.