All articles tagged with #brain resilience
Scientists at the University of Kentucky developed a mouse model that can switch the APOE gene from a high-risk to a protective form in adults, leading to improvements in Alzheimer’s disease markers and cognitive function, highlighting potential gene-based therapies for the future.
SuperAgers are individuals over 80 with memory performance comparable to much younger people, and their brains show unique biological traits that resist or resist the effects of Alzheimer's disease. Research suggests that social engagement, brain structure, and cellular differences contribute to their exceptional cognitive resilience, offering insights into potential ways to prevent or delay dementia.
A study by the Netherlands Institute for Neuroscience found that some people with Alzheimer's pathology do not show symptoms due to unique genetic and cellular factors. These resilient brains have more protective antioxidants and better waste removal, potentially pointing to new treatment avenues. Researchers aim to understand these differences to develop drugs that enhance brain resilience against Alzheimer's.
Researchers in the Netherlands discovered a subgroup of individuals with Alzheimer's pathology in their brains who never exhibited symptoms, suggesting resilience due to factors like genetics, lifestyle, and cognitive activities. This resilience may involve protective brain mechanisms such as increased antioxidant production by astrocytes and a more effective unfolded protein response. The findings highlight the potential for cognitive reserve to delay or prevent the onset of Alzheimer's symptoms despite the presence of disease markers.