All articles tagged with #age related diseases
A new study suggests that increasing apolipoprotein M (ApoM) levels could slow or prevent age-related macular degeneration (AMD) by improving cholesterol processing in the retina, potentially offering a new treatment to preserve vision and benefit heart health, with promising results in mouse models.
A study suggests that struggling to lift 5 kg could be an early indicator of various health issues in older adults, including Alzheimer's and heart disease, providing a simple, accessible way for at-home health screening.
A new study has identified three distinct 'ageing peaks' in the brain at ages 57, 70, and 78, marked by spikes in 13 proteins linked to brain aging. These findings suggest these ages are crucial for interventions to delay diseases like dementia. The research, conducted by a team from Zhengzhou University, highlights the need for a deeper understanding of the aging process, especially as the global population of those aged 65 and above is expected to exceed 1.5 billion by 2050.
Researchers at Osaka Metropolitan University have developed the Mouse Aging Proteomic Atlas, a comprehensive database mapping protein changes in major tissues of aging mice. This atlas reveals proteins linked to aging, particularly in the extracellular matrix, enhancing our understanding of molecular aging and identifying potential targets for preventing age-related diseases. The study provides valuable insights into age-related post-transcriptional dysregulation and its impact on protein expression across different tissues.
Researchers in New York have developed a revolutionary cell therapy using CAR T-cells to target and eliminate senescent cells, which contribute to age-related decline. This therapy has shown long-term effectiveness with a single treatment, potentially improving metabolic function and physical health in mice without noticeable side effects. While more research is needed before human application, the therapy's potential to revolutionize aging and age-related disease treatment is immense.
Scientists are studying the life and genes of Maria Branyas, a 116-year-old woman, to uncover the secrets behind her longevity and potentially develop cures for age-related diseases. Branyas, currently the oldest living person in the world, has an impressive health record and attributes her long life to genetics and lifestyle choices. The research aims to analyze her DNA and compare it with her middle daughter's DNA to determine the genetic factors contributing to her longevity. The findings could provide insights into addressing age-related diseases such as neurodegenerative disorders, cardiovascular diseases, and cancer.
Scientists at Scripps Research have discovered a mitochondrial protein structure, composed of the DELE1 protein, that is crucial for activating the cell's integrated stress response (ISR). This finding could have implications for the development of therapeutics for age-related diseases, such as neurodegeneration. The researchers identified that the DELE1 protein forms an octamer, or an oligomeric structure, which is necessary for initiating the ISR. Understanding and manipulating this pathway could lead to potential treatments for various disorders.
Taiwanese researchers have discovered that genetically modified stem cells can delay age-dependent deterioration in mice, rejuvenating their cells and improving their memory and heart health. This breakthrough could pave the way for advancements in healthcare and the fight against age-related diseases.