All articles tagged with #apoe
Originally Published 6 days ago — by SciTechDaily
Scientists at the University of Kentucky developed a mouse model that can switch the APOE gene from a high-risk to a protective form in adults, leading to improvements in Alzheimer’s disease markers and cognitive function, highlighting potential gene-based therapies for the future.
Originally Published 1 year ago — by Alzforum
A recent study published in Cell reveals that the risk of late-onset Alzheimer's disease associated with different APOE gene variants is linked to lysosomal dysfunction. Researchers found that the high-risk ApoE4 variant, unlike the protective ApoE2 and Christchurch variants, transports lipids into lysosomes, leading to the accumulation of lipofuscin, a toxic byproduct. This process is exacerbated by the strong binding of ApoE4 to low-density lipoprotein receptors, causing increased lipid uptake and oxidative stress in lysosomes. These findings offer new insights into the molecular mechanisms of Alzheimer's and potential therapeutic targets.
Originally Published 2 years ago — by Neuroscience News
Researchers have discovered a connection between the most common form of Alzheimer's disease (sAD) and a rarer form (fAD), shedding light on how the two types are linked. The study found that abnormal γ-cleavage of amyloid precursor protein (APP) is the common pathogenic cause of both types of Alzheimer's. The researchers also discovered that different variants of the ApoE gene can significantly impact the risk of developing sAD, with ApoE2 showing the strongest inhibitory activity on γ-cleavage of APP. This finding could help researchers develop new treatments for Alzheimer's.