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Lipid Metabolism

All articles tagged with #lipid metabolism

Dietary fats steer T cell ferroptosis to modulate immunity
science3 hours ago

Dietary fats steer T cell ferroptosis to modulate immunity

Dietary lipid composition (PUFAs/MUFAs) determines mouse T cell resistance to ferroptosis, shaping T cell homeostasis and immune responses via lipid remodeling; these diet‑induced ferroptosis effects (DEFs) are microbiota‑independent and correlate with human plasma lipid profiles, with PUFA‑containing phospholipids driven by ACSL4 underpinning TFH cell development and broader T cell–mediated immunity, including anti‑tumor responses and CAR‑T therapy. The findings suggest targeting lipid metabolism could enhance vaccines and immunotherapies.

via Nature|
#acsl4#ferroptosis#immunity
science1 year ago

APOE Variants: How Receptors and Lysosomes Influence Risk

A recent study published in Cell reveals that the risk of late-onset Alzheimer's disease associated with different APOE gene variants is linked to lysosomal dysfunction. Researchers found that the high-risk ApoE4 variant, unlike the protective ApoE2 and Christchurch variants, transports lipids into lysosomes, leading to the accumulation of lipofuscin, a toxic byproduct. This process is exacerbated by the strong binding of ApoE4 to low-density lipoprotein receptors, causing increased lipid uptake and oxidative stress in lysosomes. These findings offer new insights into the molecular mechanisms of Alzheimer's and potential therapeutic targets.

via Alzforum|
#alzheimers#apoe#genetics
Tiny Fish Reactivate Ancient Genes to Survive Prolonged Droughts
science1 year ago

Tiny Fish Reactivate Ancient Genes to Survive Prolonged Droughts

Researchers have discovered that the African turquoise killifish can survive months-long droughts by entering a state of suspended animation called diapause, utilizing ancient genes from over 473 million years ago. This adaptation involves genomic remodeling and increased production of very-long-chain fatty acids, which protect the embryos' developing organs. This finding could lead to new strategies for tissue preservation and combating age-related diseases.

via ScienceAlert|
#african-turquoise-killifish#ancient-genes#diapause
Brain Cholesterol Reduction Shows Promise in Alzheimer's Treatment
health2 years ago

Brain Cholesterol Reduction Shows Promise in Alzheimer's Treatment

New research published in the journal Neuron suggests that deposits of cholesteryl esters, a form of cholesterol, in the brain are linked to the accumulation of tau proteins, which are associated with Alzheimer's disease. The study found that mice with a high-risk tau gene and the APOE4 gene, which increases the risk of Alzheimer's, had distorted brain lipid metabolism and increased inflammation. However, when given an experimental drug that lowers lipid levels, the mice showed reduced brain damage, less tau accumulation, and lower levels of inflammation. The findings suggest that reducing brain lipid levels could potentially prevent the onset of Alzheimer's and other neurodegenerative diseases.

via Newsweek|
#alzheimers-disease#brain-damage#cholesterol
Unraveling the Mysteries of Multiple Sclerosis: Immune Cells, Fat Metabolism, and Biomarkers
health2 years ago

Unraveling the Mysteries of Multiple Sclerosis: Immune Cells, Fat Metabolism, and Biomarkers

Changes in immune cell activity, immune signaling molecules, iron regulation, and fat metabolism may explain why multiple sclerosis (MS) progresses differently in individuals. Researchers compared gene expression profiles in secondary progressive MS (SPMS) and benign MS, finding over 200 genes expressed at significantly altered levels in SPMS. SPMS patients showed increased activity in genes associated with B-cells and natural killer cells, as well as differences in cytokines, antigen presentation, lipid metabolism, and iron regulation. These findings provide insights into the molecular mechanisms underlying MS progression and may lead to the identification of new targets for preventing or slowing disease progression.

via Multiple Sclerosis News Today|
#disease-progression#gene-expression#health
Cracking the Code: How Genetics Influence Vegetarian Diets
health2 years ago

Cracking the Code: How Genetics Influence Vegetarian Diets

A study conducted by Northwestern University has found that certain genetic variations related to lipid metabolism and brain function may influence an individual's choice to follow a vegetarian diet. The study, which analyzed over 330,000 genomes, identified 34 genes potentially involved in vegetarianism. The findings suggest that genetics play a role in determining dietary preferences and may help nutritionists develop personalized dietary recommendations based on an individual's genetic makeup. Further research is needed to explore the physiological pathways underlying vegetarianism and lipid synthesis and metabolism in vegetarians compared to non-vegetarians.

via SciTechDaily|
#brain-function#diet#genetics
Surprising Enzyme Unveiled as Key Player in Leukemia's Progression
health2 years ago

Surprising Enzyme Unveiled as Key Player in Leukemia's Progression

Scientists at the University of Tsukuba have discovered a connection between the enzyme ELOVL6, involved in lipid metabolism, and the development of acute myeloid leukemia (AML). The researchers found that higher levels of ELOVL6 correspond to reduced survival rates in leukemia patients. Deleting ELOVL6 in bone marrow stem cells inhibited engraftment and prevented the development of leukemia in a mouse model. The study suggests that ELOVL6 and its associated pathways could be potential targets for novel leukemia therapies.

via SciTechDaily|
#blood-cancer#elovl6#health
Unveiling the Molecular Switch Controlling Cellular Lipid Metabolism
science-and-technology2 years ago

Unveiling the Molecular Switch Controlling Cellular Lipid Metabolism

Researchers at the University of Basel have discovered a molecular switch, known as Arf1, that regulates lipid metabolism in cells. This protein controls the storage or conversion of lipids into energy by altering the contact site between lipid droplets and mitochondria. When the body signals a need for energy, Arf1 allows lipids to enter the mitochondria, but if it is absent or overactive, the system becomes imbalanced, leading to insufficient ATP energy supply and the accumulation of fatty acids in lipid droplets. The researchers aim to further study the feedback process of Arf1 and unravel lipid trafficking in detail.

via News-Medical.Net|
#arf1-protein#energy-production#lipid-metabolism
African Killifish: The Key to Reversing Aging?
health2 years ago

African Killifish: The Key to Reversing Aging?

African Killifish muscles go through a "Benjamin Button" process and start aging backwards, returning to an "early-life" state, which gives them an opportunity to slow their aging down and live longer. Researchers suggest that drugs involved in forming certain lipids may help humans produce age-defying muscles. The study is the first to use killifish to study age-related muscle loss and highlights the important role lipid metabolism plays in age-reversing effects.

via Study Finds|
#african-killifish#aging#health
Muscles Can Reverse Aging, Says Groundbreaking Research.
health2 years ago

Muscles Can Reverse Aging, Says Groundbreaking Research.

Researchers from Monash University have discovered that as organisms age, their muscles revert to an “early-life” state, potentially prolonging life. Utilizing the African killifish as a model, the team identified a critical role of lipid metabolism in this process, suggesting that manipulation of cell metabolism could potentially slow or reverse muscle aging. The study found that our muscles seem to revert to an “early-life” condition towards the end of life, slowing down mortality. This discovery could pave the way to mitigating or even reversing the age-related decline in muscle mass and strength.

via SciTechDaily|
#african-killifish#aging#health