All articles tagged with #african turquoise killifish
Researchers used the ultra-fast-aging African turquoise killifish to model kidney aging and found that SGLT2 inhibitors slow age-related kidney damage by preserving capillaries, filtration barriers, energy metabolism, and reducing inflammation, helping explain the kidney and heart protection these drugs provide in humans and establishing the fish as a rapid aging model for testing therapies.
Researchers have discovered that the African turquoise killifish can survive months-long droughts by entering a state of suspended animation called diapause, utilizing ancient genes from over 473 million years ago. This adaptation involves genomic remodeling and increased production of very-long-chain fatty acids, which protect the embryos' developing organs. This finding could lead to new strategies for tissue preservation and combating age-related diseases.