All articles tagged with #abca7
Variants causing loss of function in ABCA7 are linked to Alzheimer's risk by disrupting lipid transport, mitochondrial function, and cellular stress responses in neurons; treatment with CDP-choline can reverse these effects, highlighting potential therapeutic strategies.
Researchers at Temple University's Lewis Katz School of Medicine are investigating the protein ABCA7 as a potential therapeutic target for Alzheimer's disease. A recent study published in Cells explored the relationship between ABCA7, cholesterol metabolism, and inflammation in human brain cells. The study found that cholesterol loss could downregulate ABCA7 in various brain cells, potentially contributing to the onset of Alzheimer's disease. Additionally, inflammation was found to suppress ABCA7 in certain brain cells. Further research is needed to fully understand the role of ABCA7 in Alzheimer's disease and develop targeted therapies.