Surprising Enzyme Unveiled as Key Player in Leukemia's Progression
Scientists at the University of Tsukuba have discovered a connection between the enzyme ELOVL6, involved in lipid metabolism, and the development of acute myeloid leukemia (AML). The researchers found that higher levels of ELOVL6 correspond to reduced survival rates in leukemia patients. Deleting ELOVL6 in bone marrow stem cells inhibited engraftment and prevented the development of leukemia in a mouse model. The study suggests that ELOVL6 and its associated pathways could be potential targets for novel leukemia therapies.