All articles tagged with #proteomics
The article discusses a study on enhancing antigen-induced cellular responses using proximity labelling techniques, with data available from various repositories and analysis code on GitHub, highlighting advances in immune signaling and proteomics methods.
This study explores the proteogenomic landscape of the human kidney and discusses its implications for cardio-kidney-metabolic health, providing data resources and analysis tools for further research.
A new study reveals that human aging accelerates around age 50, with organs aging at different rates, notably the aorta which may influence systemic aging through proteins like GAS6. The research highlights aging as a phased process with molecular upheavals, offering potential for targeted interventions and biomarkers to track organ-specific decline.
A groundbreaking study reveals that insulin resistance and type 2 diabetes are more complex than previously thought, with individual molecular signatures in muscle tissue influencing insulin sensitivity. This research paves the way for personalized diagnosis and treatment, moving beyond traditional blood tests to early detection through muscle protein analysis, potentially transforming diabetes management worldwide.
The GNPC identified a shared five-protein biomarker profile across Alzheimer's, Parkinson's, frontotemporal dementia, and ALS, which predicts APOE ε4 status with high accuracy, offering new avenues for understanding and potentially treating these diseases, though causality remains unproven.
Paleontologists have discovered preserved ancient proteins in a 24-million-year-old rhinoceros fossil, challenging previous timelines of rhino evolution and demonstrating the potential of protein analysis to study deep past species beyond the limits of ancient DNA, thereby opening new avenues for understanding evolutionary history.
Recent research has expanded the understanding of molecular glue degraders, revealing that they can target a much wider array of proteins than previously thought, including those with surface features beyond the beta-hairpin loop motif, opening new possibilities for drug development against previously 'untouchable' proteins.
Illumina is acquiring SomaLogic for $350 million to enhance its proteomics capabilities and advance its multiomics strategy, leveraging SomaLogic's data-driven proteomics technology to expand in a high-growth market and integrate with Illumina's sequencing ecosystem.
Researchers are developing an $800 blood test that measures proteins to assess real-time organ health and aging, potentially revolutionizing personalized medicine and early disease detection, with some clinics already using similar tests to guide health interventions.
Scientists used palaeoproteomics to analyze 2-million-year-old teeth from South Africa, successfully determining the biological sex of Paranthropus robustus individuals for the first time, revealing significant genetic diversity within the genus and providing new insights into early hominin evolution.
AI tools like AlphaFold, Casanovo, and InstaNova are revolutionizing biology by predicting complex protein structures, inferring unknown sequences, and enhancing peptide identification, with applications extending to archaeology and medical research, marking a new era of scientific discovery.
Small pieces of tooth enamel from 2 million-year-old fossils in South Africa have been analyzed using proteomics, revealing new insights into early human relatives, including sex determination and potential species diversity, highlighting the limitations of traditional methods and the promise of advanced protein analysis in paleoanthropology.
A new proteomic blood test developed by Australian scientists can rapidly and accurately screen newborns for thousands of rare inherited diseases from just a small blood sample, potentially replacing multiple current tests, reducing diagnosis time, and improving early detection and treatment options.
A study published in Nature Aging identifies 13 proteins in blood plasma that are strongly associated with brain aging, with significant changes in their concentrations observed at ages 57, 70, and 78. These proteins, including Brevican (BCAN) and GDF15, are linked to neurodegenerative disorders like dementia and stroke. The research, based on data from the UK Biobank, suggests that monitoring these proteins could aid in early intervention strategies for brain aging. The study emphasizes the need for further research across diverse ages and ethnicities.
Researchers at Washington University have developed a proteomics-based model using cerebrospinal fluid (CSF) to better understand and predict Alzheimer's disease. By analyzing CSF proteins and their genetic links, they identified 38 proteins likely involved in Alzheimer's, with 15 being targetable by existing drugs. This approach could enhance treatment strategies for Alzheimer's and other neurological conditions, offering a more accurate prediction model than current genetics-based methods.