Tag

Proteomics

All articles tagged with #proteomics

health4 days ago•16 min saved

Aging Accelerates at 50 Across the Body, New Study Finds

A study analyzing 516 tissue samples from 76 organ donors aged 14–68 shows rapid aging begins around age 50, with different organs aging at different rates. The findings support aging as a systemic, nonuniform process and highlight the need for further research. In the meantime, NIH/CDC guidance emphasizes regular exercise, a nutrient-rich diet, portion control, and social engagement to maintain health and quality of life into later years.

via Good.is|

#aging #health #longevity

science8 days ago•66 min saved

Single-cell proteomics maps human liver zonation and its fragility in diseased tissue

Researchers used advanced scDVP to profile hundreds of hepatocytes from 18 people, building a high-resolution map of protein gradients along the liver's porto–central axis. They quantified ~2,500 proteins per cell, showed roughly half are zonated, and introduced gradient-based analysis to quantify zonation without binning. Cross-species comparison with mice revealed shared and human-specific zonation features; in tissues with disrupted architecture, zonation is broadly lost. The study delivers an open-access liver proteome resource and a framework applicable to spatial proteomics.

via Nature|

#liver #proteomics #science

science1 month ago•85 min saved

Proteins from a 1531 medical text hint at Renaissance hair cures and odd remedies

A proteomics analysis of Bartholomäus Vogtherr’s 1531 medical manuals recovered 111 proteins from the pages, including traces that could match plants (beech, watercress, rosemary) and animals (lizard, tortoise shell, hippopotamus). Notably, protein near hair-growth recipes suggests readers experimented with lizard heads for hair loss and hippo-derived ingredients for dental/mouth issues, illustrating how Renaissance readers tested unconventional cures and shedding light on early modern household science, per a study in the American Historical Review.

via Live Science|

#ancient-remedies #bartholomaus-vogtherr #historical-manuscripts

science5 months ago•24 min saved

Enhanced Immunotherapy Through Proximity Labeling Techniques

The article discusses a study on enhancing antigen-induced cellular responses using proximity labelling techniques, with data available from various repositories and analysis code on GitHub, highlighting advances in immune signaling and proteomics methods.

via Nature|

#cell-signaling #immune-response #proteomics

science6 months ago•28 min saved

Proteogenomic Insights into Kidney Health and Metabolic Diseases

This study explores the proteogenomic landscape of the human kidney and discusses its implications for cardio-kidney-metabolic health, providing data resources and analysis tools for further research.

via Nature|

#cardio-kidney-metabolic-health #genomics #kidney

science7 months ago•5 min saved

Body's Aging Accelerates Around Age 50, Study Finds

A new study reveals that human aging accelerates around age 50, with organs aging at different rates, notably the aorta which may influence systemic aging through proteins like GAS6. The research highlights aging as a phased process with molecular upheavals, offering potential for targeted interventions and biomarkers to track organ-specific decline.

via ZME Science|

#aging #molecular-signals #organs

health7 months ago•5 min saved

Innovative Study Promises Advances in Diabetes Detection and Management

A groundbreaking study reveals that insulin resistance and type 2 diabetes are more complex than previously thought, with individual molecular signatures in muscle tissue influencing insulin sensitivity. This research paves the way for personalized diagnosis and treatment, moving beyond traditional blood tests to early detection through muscle protein analysis, potentially transforming diabetes management worldwide.

via The Brighter Side of News|

#diabetes #health #insulin-resistance

health7 months ago•4 min saved

Shared Biomarker Profiles and Proteomic Insights in Neurodegenerative Diseases

The GNPC identified a shared five-protein biomarker profile across Alzheimer's, Parkinson's, frontotemporal dementia, and ALS, which predicts APOE ε4 status with high accuracy, offering new avenues for understanding and potentially treating these diseases, though causality remains unproven.

via Medical Xpress|

#apoe-e4 #biomarkers #health

science7 months ago•4 min saved

Ancient Proteins Reveal New Insights into Rhino Evolution and Paleontology

Paleontologists have discovered preserved ancient proteins in a 24-million-year-old rhinoceros fossil, challenging previous timelines of rhino evolution and demonstrating the potential of protein analysis to study deep past species beyond the limits of ancient DNA, thereby opening new avenues for understanding evolutionary history.

via Indian Defence Review|

#ancient-proteins #fossil-analysis #paleontology

science7 months ago•3 min saved

Molecular Glues and Data Mining Revolutionize Oncology Drug Development

Recent research has expanded the understanding of molecular glue degraders, revealing that they can target a much wider array of proteins than previously thought, including those with surface features beyond the beta-hairpin loop motif, opening new possibilities for drug development against previously 'untouchable' proteins.

via Phys.org|

#crbn #drug-development #molecular-glues

business8 months ago•5 min saved

Illumina's Acquisition of SomaLogic Boosts Proteomics and Multiomics Strategy

Illumina is acquiring SomaLogic for $350 million to enhance its proteomics capabilities and advance its multiomics strategy, leveraging SomaLogic's data-driven proteomics technology to expand in a high-growth market and integrate with Illumina's sequencing ecosystem.

via Illumina|

#acquisition #business #illumina

health8 months ago•7 min saved

Revolutionary Blood Test Offers Real-Time Insights into Aging and Longevity

Researchers are developing an $800 blood test that measures proteins to assess real-time organ health and aging, potentially revolutionizing personalized medicine and early disease detection, with some clinics already using similar tests to guide health interventions.

via Business Insider|

#blood-test #health #longevity

science9 months ago•2 min saved

Ancient Teeth Uncover Sex and Secrets of Early Human Relatives

Scientists used palaeoproteomics to analyze 2-million-year-old teeth from South Africa, successfully determining the biological sex of Paranthropus robustus individuals for the first time, revealing significant genetic diversity within the genus and providing new insights into early hominin evolution.

via IFLScience|

#fossil-teeth #genetic-diversity #paranthropus

science9 months ago•4 min saved

AI Breakthrough Unveils Long-Standing Biological Mysteries and Unknown Molecules

AI tools like AlphaFold, Casanovo, and InstaNova are revolutionizing biology by predicting complex protein structures, inferring unknown sequences, and enhancing peptide identification, with applications extending to archaeology and medical research, marking a new era of scientific discovery.

via Rude Baguette|

#ai #alphafold #instanova

science9 months ago•4 min saved

Ancient Teeth and Proteins Uncover Secrets of Human Evolution

Small pieces of tooth enamel from 2 million-year-old fossils in South Africa have been analyzed using proteomics, revealing new insights into early human relatives, including sex determination and potential species diversity, highlighting the limitations of traditional methods and the promise of advanced protein analysis in paleoanthropology.

via Live Science|

#ancient-dna #fossil-analysis #hominin-evolution