Tag

Apoe E4

All articles tagged with #apoe e4

science1 month ago•4 min saved

Aging Memory Decline Tied to Widespread Brain Changes Across Regions

A large multicohort study of 3,737 cognitively healthy participants with 10,343 MRI scans and 13,460 memory assessments finds episodic memory declines with age are linked to broad brain tissue loss rather than a single region, with stronger effects after age 60 and more pronounced in APOE ε4 carriers; results imply aging-related cognitive decline shares mechanisms with neurodegenerative diseases and may require early, multi-area interventions across the brain.

via ScienceAlert|

#aging #apoe-e4 #hippocampus

health-and-medicine1 month ago•7 min saved

Genetic edge helps super agers stay mentally sharp into their 80s

A Vanderbilt-led study of 18,080 participants finds that people over 80 with unusually strong memory (super agers) carry fewer APOE-ε4 Alzheimer’s risk genes and more APOE-ε2 protective variants than their peers. Super agers were 68% less likely to carry ε4 than 80+ individuals with Alzheimer's and 19% less likely than cognitively normal peers, while they were 28% more likely to carry ε2, and 103% more likely than those with Alzheimer’s dementia to have this protective variant. As the largest study of super agers to date, the findings suggest a genetic basis for exceptional cognitive aging and may guide future dementia resilience research.

via ScienceDaily|

#alzheimers-disease #apoe-e2 #apoe-e4

science1 month ago•5 min saved

Genetic Variants Linked to Dementia Resilience in Superagers, Study Finds

In a study of 18,080 participants (1,623 superagers aged 80+, 8,829 with Alzheimer's, 7,628 controls), researchers found that superagers are less likely to carry the APOE-e4 Alzheimer's-risk variant and more likely to carry APOE-e2, suggesting genetics contribute to exceptional aging and reduced dementia risk. The pattern held in non-Hispanic White groups, highlighting a potential genetic basis for dementia resilience, though lifestyle and other factors remain important, and more diverse research is needed.

via ScienceAlert|

#alzheimers-disease #apoe-e2 #apoe-e4

health7 months ago•4 min saved

Shared Biomarker Profiles and Proteomic Insights in Neurodegenerative Diseases

The GNPC identified a shared five-protein biomarker profile across Alzheimer's, Parkinson's, frontotemporal dementia, and ALS, which predicts APOE ε4 status with high accuracy, offering new avenues for understanding and potentially treating these diseases, though causality remains unproven.

via Medical Xpress|

#apoe-e4 #biomarkers #health