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Genomics

All articles tagged with #genomics

technology3 days ago

Illumina outlines 18-month NovaSeq X upgrades to boost quality, throughput and speed

Illumina announced an 18‑month roadmap for the NovaSeq X system featuring a Q70 quality score, a 40% output increase to 35 billion reads, and 30% faster runtimes (14B reads in 20–22 hours). The plan adds staggered starts, new flow cells and DRAGEN software to broaden multiomics, oncology and genetics applications. Rollout will span all NovaSeq X installations (~890 systems) and aims to enable higher-quality data at lower cost, advancing oncology, MRD testing and rare-disease research.

via Illumina|
#genomics#high-throughput-sequencing#illumina
Cats Mirror Human Breast Cancer, Paving Cross-Species Treatment Paths
science7 days ago

Cats Mirror Human Breast Cancer, Paving Cross-Species Treatment Paths

A Science study analyzing nearly 500 feline tumors from five countries across 13 cancer types finds genetic similarities with human cancers, notably FBXW7 mutations in feline mammary tumors that mirror aggressive human cases; two chemotherapy drugs show promise against these tumors in cats, suggesting a potential path for new treatments in humans and enabling faster veterinary testing—highlighting cats as a valuable model for cancer biology and shared environmental factors.

via CTV News|
#breast-cancer#cancer-research#cats
Comb Jellies Crown the Earliest Split in the Animal Family Tree
science24 days ago

Comb Jellies Crown the Earliest Split in the Animal Family Tree

New research used chromosome-level gene-order analysis to compare 14 gene groups in comb jellies, sea sponges, and closely related single-celled relatives. The patterns show conserved gene positions in comb jellies and non-animal relatives but greater genomic rearrangement in sponges, identifying comb jellies as the earliest animal branch and the sister lineage to all other animals, prompting a rethink of how key animal features evolved.

via Indian Defence Review|
#comb-jellies#evolution#genomics
Biobank DNA leftovers unlock secrets of Epstein–Barr virus
genomics28 days ago

Biobank DNA leftovers unlock secrets of Epstein–Barr virus

Researchers show that non-human DNA discarded during whole-genome sequencing can be repurposed to detect and quantify Epstein–Barr virus DNA in human cells, using a method described by Nyeo et al. in Nature. This population-scale approach lets biobanks reveal persistent EBV DNA and its links to complex diseases, turning sequencing byproducts into a new source of epidemiological insight.

via Nature|
#biobanks#epstein-barr-virus#genomics
DeepMind's AlphaGenome Lets AI Scan a Full Million-Letter Genome at Once
science28 days ago

DeepMind's AlphaGenome Lets AI Scan a Full Million-Letter Genome at Once

DeepMind's AlphaGenome, described in Nature, can analyze up to about 1 megabase of DNA at a time—roughly a million letters—outperforming prior AI models in 25 of 26 tests and predicting thousands of functional genomic tracks along with nearly 6,000 human genetic signals. Trained on both human and mouse genomes, it aims to illuminate how coding and non-coding regions interact and regulate genes. While praised as a milestone, experts caution that data quality and standardization remain limiting factors; the model could help diagnose rare genetic diseases, identify cancer mutations, and reveal drug targets, but it isn’t a complete solution yet.

via Gizmodo|
#alphagenome#artificial-intelligence#dna-sequencing
DeepMind's AlphaGenome maps the dark genome to disease clues
science29 days ago

DeepMind's AlphaGenome maps the dark genome to disease clues

DeepMind's AlphaGenome is a sequence-to-function AI that can scan up to one million DNA letters at once to map the dark genome, predict how mutations affect gene expression and splicing, and flag disease-linked variants and potential drug targets, offering a major advance for obesity, diabetes, cancer, and other conditions—though it's still imperfect and will require refinement.

via BBC|
#ai#dark-genome#deepmind
AlphaGenome: DeepMind’s AI Maps the Genome’s Hidden Rules
science29 days ago

AlphaGenome: DeepMind’s AI Maps the Genome’s Hidden Rules

DeepMind’s AlphaGenome trains an AI on vast molecular data to forecast how mutations and regulatory DNA elements alter gene activity, extending the AlphaFold-era breakthrough from proteins to the genome; experts see it as a major engineering advance with potential for cancer and disease research, but stress it remains a predictive tool—its scope is limited to single mutations in a given genome, its predictions don’t capture all splice-site complexities, and clinical use still requires lab validation.

via The New York Times|
#artificial-intelligence#dna#gene-regulation
Illumina's Billion Cell Atlas Aims to Speed Drug Discovery with AI-powered Insights
technology1 month ago

Illumina's Billion Cell Atlas Aims to Speed Drug Discovery with AI-powered Insights

Illumina unveiled the Billion Cell Atlas, a massive dataset mapping how gene perturbations affect 200 cell lines to accelerate drug discovery via AI-powered models and virtual cells; with about 150 million cells generated so far and a goal of a billion by year-end, the company has signed on Merck, AstraZeneca, and Eli Lilly as initial customers.

via statnews.com|
#artificial-intelligence#billion-cell-atlas#drug-discovery
business1 month ago

Illumina Names Dr. Eric Green as New Chief Medical Officer

Illumina has appointed Dr. Eric Green, a renowned genomics leader and former NHGRI director, as its new Chief Medical Officer to advance the clinical application of genomics and expand access to precision medicine. The company also announced the departure of its chief commercial officer, Everett Cunningham, who will become a CEO of a life science tools company.

via Illumina|
#business#chief-medical-officer#dr-eric-green