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Brain Aging

All articles tagged with #brain aging

A Year of Cardio May Make Your Brain Look Younger
health9 days ago

A Year of Cardio May Make Your Brain Look Younger

A 12-month randomized trial found that healthy adults who followed a structured aerobic program (about 150 minutes per week) had brains that appeared roughly 0.6 years younger on MRI than those who did not, with the difference approaching a full year. The change was modest and not explained by a single measured factor, suggesting multiple potential mechanisms. While larger studies are needed to link brain-age reductions to dementia risk, the findings support following current exercise guidelines to help keep the brain biologically younger into midlife.

via SciTechDaily|
#aerobic-exercise#brain-aging#cognitive-health
Lifetime cannabis use linked to younger-looking brains in a 25k-participant study
science17 days ago

Lifetime cannabis use linked to younger-looking brains in a 25k-participant study

A large UK Biobank imaging study of over 25,000 participants aged 44–81 found that lifetime cannabis users have brain connectivity patterns that resemble younger brains and outperformed non-users on several cognitive tests, with aging-related networks showing opposite changes; however, being cross-sectional and based on lifetime use, the study cannot establish causation and the effects are modest.

via Boing Boing|
#brain-aging#cannabis#cognition
DMTF1: A Molecular Switch to Rejuvenate Aging Brain Cells
science23 days ago

DMTF1: A Molecular Switch to Rejuvenate Aging Brain Cells

Researchers have identified the transcription factor DMTF1 as a key regulator that preserves neural stem cell activity in aging brains. In aging models with telomere damage, DMTF1 levels drop and neural stem cell regeneration declines; reactivating DMTF1 restores regenerative capacity and reveals its role in activating helper genes that open chromatin for growth-related genes. This suggests potential therapies to slow cognitive aging by boosting neural stem cell function, though most work so far is in vitro, with the long-term aim of developing small molecules to safely enhance DMTF1 without increasing brain tumor risk.

via SciTechDaily|
#brain-aging#dmtf1#neural-stem-cells
A Year of Exercise Could Make Your Brain Biologically Younger
health28 days ago

A Year of Exercise Could Make Your Brain Biologically Younger

A 12-month trial of 130 healthy adults (26–58) found that following WHO guidelines (about 150 minutes/week of moderate-to-vigorous exercise) led to brains that appeared roughly 0.6 years biologically younger on MRI than controls, while those who maintained usual routines looked about 0.35 years older. The difference approached statistical significance but was not itself definitive. The researchers couldn’t pinpoint the exact mechanism, with possibilities including subtle brain-structure changes, inflammation, or vascular factors, and long-term effects remain to be studied.

via ScienceAlert|
#aging#brain-aging#cognitive-health
Lithium in the Brain Sparks a Ten-Year Alzheimer’s Breakthrough
science29 days ago

Lithium in the Brain Sparks a Ten-Year Alzheimer’s Breakthrough

Harvard researchers show lithium naturally exists in the brain and supports neuron function; lithium depletion is an early Alzheimer’s change and is reduced when amyloid plaques bind lithium. In mice, losing brain lithium accelerates disease, while a lithium orotate compound can prevent or reverse pathology, prompting planned clinical trials; researchers caution against self-medicating until trials establish safety and efficacy.

via Harvard Gazette|
#alzheimers-disease#amyloid#brain-aging
OTULIN Emerges as Master Regulator to Rewire Brain Aging
science1 month ago

OTULIN Emerges as Master Regulator to Rewire Brain Aging

A study identifies OTULIN as a high-level regulator in neurons that controls gene expression and RNA metabolism, shaping tau biology in brain aging and Alzheimer's disease. Partial inhibition of OTULIN reduced pathogenic tau, while CRISPR deletion nearly abolished tau by silencing MAPT mRNA, but also caused widespread transcriptome changes. The work suggests therapies could recalibrate neuronal regulatory networks to counter aging and neurodegeneration, though complete loss of OTULIN would be harmful and requires precise tuning.

via The Debrief|
#alzheimers-disease#brain-aging#gene-expression
Mind Diet Linked to Slower Biological Aging and Broad Brain-Health Benefits
dementia1 month ago

Mind Diet Linked to Slower Biological Aging and Broad Brain-Health Benefits

A UK Biobank study of about 170,000 adults over a median of ten years found that high adherence to the MIND diet—rich in leafy greens, berries, nuts, whole grains, and fish—was linked to lower risk of dementia and stroke and fewer depression and anxiety symptoms, along with slower biological aging and preserved brain volumes; in contrast, high intake of ultra-processed foods predicted higher risks for dementia, depression, anxiety, and Parkinson's disease. The findings were validated in American and Chinese cohorts, and potential pathways include improved metabolism and aging biomarkers (e.g., GDF-15). Mendelian randomization suggested possible causality, but the study remains observational and randomized trials are needed.

via PsyPost|
#brain-aging#dementia#mind-diet
OTULIN Regulates Tau in Neurons, Opening Alzheimer’s Therapy Avenues
science1 month ago

OTULIN Regulates Tau in Neurons, Opening Alzheimer’s Therapy Avenues

Researchers at the University of New Mexico found that OTULIN, an enzyme known for immune regulation, also controls tau production in neurons. By inhibiting OTULIN with a small molecule or knocking out the OTULIN gene, they stopped new tau formation and cleared existing tau in human neuron models, suggesting a novel target for treating Alzheimer’s disease and related tauopathies. The findings also linked OTULIN to RNA metabolism and inflammatory pathways, and researchers note the need to study effects across different brain cell types before pursuing therapies.

via SciTechDaily|
#alzheimers-disease#brain-aging#neurodegenerative-diseases
Engaging in Creative Activities May Help Slow Brain Aging
health-and-science2 months ago

Engaging in Creative Activities May Help Slow Brain Aging

Engaging in creative activities like dancing, music, art, or playing strategy video games is linked to a younger-looking brain and slower brain aging, with long-term practice providing stronger benefits. Even short-term creative training can improve brain aging markers, suggesting that regular creative engagement supports neural health and cognitive resilience.

via Neuroscience News|
#brain-aging#brain-health#brain-plasticity