All articles tagged with #oxidative stress
A study of 23 runners found that very long-distance races can injure red blood cells, reducing their flexibility and accelerating aging due to inflammation and oxidative stress, with longer races like the UTMB causing more damage; researchers caution the small sample size and call for more research into training and recovery strategies to minimize cellular damage.
A study in Blood Red Cells & Iron finds ultramarathon races can damage red blood cells, making them less flexible due to mechanical stress and inflammation/oxidative stress; signs of accelerated aging appear after 40‑km races and worsen after 171‑km events, though long‑term effects and duration of damage are unclear; findings could influence training, recovery, and blood storage research, but the study has a small sample size and limited sampling points.
New lab and observational evidence suggests the sugar substitute erythritol can damage cells of the blood-brain barrier, trigger oxidative stress, and lower nitric oxide while raising endothelin-1, potentially narrowing cerebral vessels and hindering clot dissolution—factors that could elevate stroke risk; these findings align with studies linking erythritol to higher cardiovascular events, though most experiments used isolated cells and require validation in more realistic models.
A study suggests that oxidative stress may contribute to repetitive behaviors seen in autism and related disorders, with specific biomarkers identified that could aid early detection and treatment, though causality remains to be confirmed.
Research in mice shows that protecting T cell telomeres from oxidative damage with targeted antioxidants can prevent T cell exhaustion caused by tumor environments, potentially enhancing cancer immunotherapy effectiveness, including CAR-T therapy.
A mouse study suggests that a ketogenic diet may accelerate aging in males but not in females, possibly due to estrogen's protective effects; further research is needed to see if these findings apply to humans.
Research reveals that the distinct 'old people smell' is caused by increased levels of the chemical 2-nonenal, which results from oxidative stress breaking down skin fats. Consuming mushrooms, rich in antioxidants like ergothioneine and spermidine, can help reduce this odor by neutralizing 2-nonenal, as traditional methods like showering and perfume are ineffective.
Eating about 22 almonds a day may help reduce oxidative stress and improve overall oxidative health, potentially extending health span, according to a systematic review of multiple studies. Almonds are rich in antioxidants like vitamin E and polyphenols, which combat cellular damage, and incorporating them into the diet can be a proactive, low-risk strategy for disease prevention. However, due to their calorie content, almonds should replace other snacks rather than be added on top of a normal diet.
The study reveals that female kidney tissues are resistant to ferroptosis and acute kidney injury due to the protective effects of oestradiol, which acts through non-genomic antioxidant mechanisms and ESR1-dependent pathways, while male tissues are more susceptible due to higher ether lipid plasticity and lower hydropersulfide levels.
A new study suggests that abnormal glycogen buildup in neurons may contribute to Alzheimer's disease by disrupting energy management and increasing oxidative stress, and that breaking down glycogen could offer a new therapeutic approach.
A study published in Cell Press reveals that intermittent fasting, while beneficial for metabolic health, may slow hair regrowth by causing hair follicle stem cells (HFSCs) to undergo apoptosis due to oxidative stress and free fatty acid buildup. In mice, fasting led to slower hair regeneration, and a small human trial showed an 18% reduction in hair growth speed. Antioxidants like vitamin E were found to mitigate these effects, suggesting potential solutions to this unintended consequence of fasting.
Researchers have identified accumulated DNA damage in the retina as a key factor in age-related macular degeneration (AMD), a leading cause of blindness in people over 50. The study, published in Aging Cell, suggests that targeting specific retinal cells could lead to treatments that slow or stop AMD progression. The research highlights the importance of DNA repair in maintaining retinal health and suggests potential interventions to counteract oxidative stress and enhance DNA repair. The study involved collaboration from multiple universities and was supported by various foundations and the NIH.
A recent study presented at Discover BMB 2024 suggests a correlation between extended ingestion of reheated cooking oils and accelerated neurodegeneration, as evidenced by higher levels of neurotoxicity in rats fed diets high in such oils. The consumption of reheated oils disrupts the gut-brain-liver axis, leading to increased oxidative stress and inflammation, precursors to neurodegenerative conditions. Reheating oils at high temperatures leads to the formation of harmful compounds, impacting human health with elevated cholesterol levels, inflammation, and potential liver damage. Dietary interventions rich in omega-3 fatty acids, antioxidants, and probiotics are recommended to mitigate these risks.
Researchers from Northwestern University and the University of Wisconsin-Madison have developed a pioneering approach to combat neurodegenerative diseases such as Alzheimer's, Parkinson's, and ALS by targeting the body's antioxidant response. Using protein-like polymers (PLPs) to disrupt the Keap1/Nrf2 protein-protein interaction, the study introduces a promising therapeutic strategy to enhance cellular protection against oxidative stress implicated in these conditions. The innovative PLP technology offers a versatile and effective method for targeting transcription factors and disordered proteins, potentially revolutionizing the development of therapeutics for neurodegenerative diseases.
A study has identified 7-dehydrocholesterol as a natural inhibitor of ferroptosis, a form of cell death driven by lipid peroxidation. The research sheds light on the role of 7-dehydrocholesterol-derived oxysterols in regulating ferroptosis sensitivity and provides insights into the mechanisms of this type of cell death. The data and materials supporting the findings are available in the main text, figures, and extended data figures, as well as in a repository for (epi)lipidomics experiments.