Tag

Medicine

All articles tagged with #medicine

medicine4 hours ago•6 min saved

Pomegranate Leaves Yield Molecule That Dismantles TTR Amyloid Fibrils

Researchers at Kumamoto University identified 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG) from pomegranate leaves and branches that selectively dismantles preexisting transthyretin (TTR) amyloid fibrils in vitro, in vivo, and with patient-derived fibrils ex vivo, reducing deposits and improving healthspan and lifespan in a C. elegans model. Unlike amyloid-β, PGG targets TTR aggregates specifically, suggesting a promising natural lead for treating TTR amyloidosis, though safety and efficacy in humans remain to be established.

via SciTechDaily|

#amyloidosis #medicine #natural-product

technology8 days ago•1 min saved

AI in the Exam Room: A Doctor's Practical Guide to Safe Health Advice

A physician argues that AI can empower patients when used to enhance medical care rather than replace it, noting that many already consult AI for health advice. While AI offers valuable information, it also poses risks to the doctor–patient relationship and can fuel anxiety. The recommended approach is to use AI to prepare for and inform conversations with doctors, not to substitute professional medical care.

via The New York Times|

#ai #ai-ethics #doctor-patient-relationship

medicine20 days ago•5 min saved

Selective CAR-T targets IGHV4-34, sparing healthy immunity in lymphoma mice

A CART4-34 CAR-T therapy targets the IGHV4-34 gene in B-cell cancer, destroying lymphoma cells in mice as effectively as CD19 CAR-T while sparing healthy B cells and avoiding immune suppression; the approach could also be used to treat autoimmune conditions such as lupus, but human trials are needed.

via Nature|

#autoimmune-diseases #car-t-therapy #diffuse-large-b-cell-lymphoma

health1 month ago•5 min saved

Six Health Podcasts to Decode Medicine and Policy

A roundup of six accessible health-and-medicine podcasts—This Podcast Will Kill You, Bodies, Psychiatry & Psychotherapy Podcast, Sawbones, Emergency Medicine Cases, and The Pulse—each blending expert insight, storytelling, and investigative reporting on topics from disease history to medical misinformation and U.S. healthcare policy.

via The New York Times|

#health #medicine #misinformation

technology1 month ago•5 min saved

The Pitt's AI in Medicine: Time-saving promise meets real-world limitations

The Pitt Season 2's '8:00 AM' features Dr. Baran Al-Hashimi introducing an AI app that listens to patient visits and auto-summarizes charts, claiming 80% less charting time and 20% more bedside time, but it incorrectly logs a medication—highlighting AI’s promise alongside flaws. While the piece notes a claimed 98% accuracy, it explains that AI transcription can be very accurate in quiet settings but drops in busy ERs, and large-language models still hallucinate (GPT-5.2 averages ~10.9%, ~5.8% with internet). The article argues AI should augment—not replace—doctors and emphasizes empathy at the bedside, also citing real-world radiology productivity gains (~40%) from AI. A disclosure about Mashable’s parent company’s lawsuit against OpenAI is mentioned.

via Mashable|

#ai #generative-ai #healthcare

business1 month ago•0 min saved

AI Revolutionizes Pharma and Drug Development

AI is significantly improving the pharmaceutical industry by addressing the high failure rate and lengthy, costly process of drug development, which can take over a decade and cost nearly $3 billion per successful drug.

via The Economist|

#ai #artificial-intelligence #business

health2 months ago•9 min saved

The Rise, Fall, and Revival of Testosterone in Medicine

The article discusses the historical decline and recent resurgence of testosterone therapy in medicine, highlighting how misconceptions, particularly linking testosterone to prostate cancer, led to its decline. Abraham Morgentaler played a key role in challenging these beliefs through clinical evidence, showing that testosterone therapy is safe for men with hypogonadism and emphasizing the importance of considering individual patient experiences. The piece also explores the cultural and medical biases that have hindered the acceptance of testosterone treatment.

via statnews.com|

#health #hormone-therapy #medical-history

medicine3 months ago•112 min saved

Fibroblast Niches Drive Crohn’s Fistula Formation

This study uses spatial transcriptomics and single-cell analysis to uncover how specialized fibroblast niches, particularly FAS cells, contribute to the formation, progression, and persistence of Crohn's fistulae, highlighting their roles in tissue remodeling, immune regulation, and epithelial regeneration, with implications for targeted therapies.

via Nature|

#crohns-disease #fibroblasts #fistulae

health3 months ago•3 min saved

New Evidence Highlights Fruits and Vegetables as Natural Medicine

Recent studies highlight that prescribing fruits and vegetables can significantly improve health outcomes, such as lowering blood pressure and reducing the risk of heart attacks and strokes, emphasizing the role of diet as medicine.

via NPR|

#blood-pressure #diet-related-diseases #fruits-and-vegetables

medicine3 months ago•3 min saved

VEXAS Syndrome: UBA1 Mutations Drive Inflammation and Myeloid Bias

The study investigates how UBA1 mutations in VEXAS syndrome lead to inflammation and myeloid cell bias, revealing mechanisms involving aberrant cell death and ubiquitin pathway defects, and suggesting potential therapeutic targets.

via Nature|

#cell-death #inflammation #medicine

medicine4 months ago•80 min saved

mRNA COVID Vaccines Enhance Cancer Immunotherapy Effectiveness

COVID-19 mRNA vaccines enhance the effectiveness of immune checkpoint inhibitors in cancer treatment by stimulating innate and adaptive immune responses, increasing tumor PD-L1 expression, and potentially restoring immune sensitivity in 'cold' tumors, leading to improved survival outcomes in patients with NSCLC and melanoma.

via Nature|

#cancer-immunotherapy #covid-19-vaccines #immune-checkpoint-blockade

education4 months ago•3 min saved

Stanford Welcomes Its First Female J.D./M.D. Candidate

Josie Pearce becomes Stanford's first female J.D./M.D. candidate, blending her passions for law, medicine, and health policy, inspired by her personal experience with lupus and her interest in public health.

via The Stanford Daily|

#education #female #jdmd

medicine4 months ago•61 min saved

Innovative Multi-Omics and Mapping Techniques Enhance Lung Cancer Treatment Predictions

This study develops spatial multi-omics and machine learning-based biomarkers to predict immunotherapy outcomes in advanced non-small cell lung cancer, highlighting the roles of immune cell spatial organization, macrophage PD-L1 expression, and gene signatures in resistance and response, validated across multiple cohorts.

via Nature|

#biomarkers #immunotherapy #medicine

health5 months ago•5 min saved

Medical Experts Debunk and Clarify Claims on Vaccines, Autism, and Pregnancy

A pediatrician critiques RFK Jr.'s claims about vaccines and acetaminophen, emphasizing the importance of scientific methodology and evidence-based medicine over feelings-based or conclusion-driven approaches, warning against the dangers of misinformation that undermines trust in scientific processes.

via Slate|

#evidence-based-medicine #fact-checking #health

medicine5 months ago•77 min saved

Dana-Farber Develops AI-Powered Tool for Rapid Leukemia Classification

The article presents a rapid epigenomic classification method for acute leukemia using nanopore sequencing and machine learning, based on a comprehensive DNA methylation reference cohort, enabling faster and more precise diagnosis that can complement traditional diagnostic workflows.

via Nature|

#acute-leukemia #dna-methylation #epigenomic-classification