All articles tagged with #neurodevelopmental disorders
Researchers created a humanized CHD3 R1025W mouse model of SNIBCPS and used a TadA-embedded adenine base editor delivered by dual AAVs to correct the pathogenic A•T base pair in the brain, restoring CHD3 protein levels and rescuing social, cognitive, and motor deficits; supplementary nonhuman primate work showed widespread neuronal transduction, supporting translational potential for CHD3-related neurodevelopmental disorders.
Israeli scientists used CRISPR technology to identify hundreds of genes crucial for early brain development, uncovering new insights into the genetic basis of autism and discovering a new neurodevelopmental disorder linked to the PEDS1 gene, with findings published in Nature Neuroscience.
Research shows that delivering the protein pleiotrophin (Ptn) to astrocytes in the brain can reverse neural connection and activity changes in mouse models of Down syndrome, suggesting potential for future therapies targeting brain wiring in neurodevelopmental disorders.
This article reviews recent advances in understanding human and mammalian brain development through genetic, cellular, and molecular studies, highlighting the use of single-cell genomics, spatial transcriptomics, and organoid models to elucidate neurodevelopmental processes and disorders.
A study finds that children born to mothers who had COVID-19 during pregnancy are at a higher risk of neurodevelopmental issues like speech delays and autism by age 3, especially if infection occurs in the third trimester, highlighting the importance of preventing COVID-19 during pregnancy.
A large study suggests that children born to mothers with gestational diabetes have a higher risk of developing autism and ADHD, though causality is not established, and further research is needed. The study highlights the potential impact of gestational diabetes on long-term child neurodevelopment, alongside genetic and environmental factors.
The article discusses the use of CRISPR activation techniques to address SCN2A-related neurodevelopmental disorders, with data available from RNA sequencing studies and various mouse models, aiming to develop targeted gene therapies.
A large study involving over nine million pregnancies links gestational diabetes to increased risks of ADHD and autism in children, as well as cognitive decline in mothers, highlighting the importance of managing maternal glucose levels during pregnancy.
A study reveals that previously overlooked 'junk DNA,' specifically LINE-1 transposons, actively influences early brain development and may be linked to neurological diseases, challenging the notion that non-coding DNA is irrelevant.
A comprehensive study analyzing over 100,000 participants suggests that prenatal exposure to acetaminophen may be linked to higher risks of autism and ADHD in children, prompting calls for cautious use and further research.
Scientists at UC San Diego have identified a specific DNA region called HAR123 that acts as a molecular enhancer influencing brain development and cognitive flexibility in humans, providing insights into what makes the human brain unique and its evolution, with potential implications for understanding neurodevelopmental disorders like autism.
A comprehensive review using the Navigation Guide methodology indicates that prenatal acetaminophen use is likely associated with an increased risk of neurodevelopmental disorders such as ADHD and ASD in children, supported by consistent findings across multiple high-quality studies, though some sibling-controlled studies show null results possibly due to methodological limitations. Caution is advised for pregnant women regarding acetaminophen consumption to protect fetal neurodevelopment.
Researchers at UC San Diego identified the genetic region HAR123, a transcriptional enhancer that influences neural development and may explain human-specific cognitive traits like flexibility, with implications for understanding brain evolution and disorders such as autism.
A study using MRI scans of children under 13 with restrictive eating disorders found structural brain differences, such as thinner cortex and reduced brain volume, which may be linked to behaviors and other neurodevelopmental conditions like OCD and autism, highlighting the importance of treating these disorders as distinct but related conditions.
A large-scale study found that autism and ADHD, despite often co-occurring, have distinct brain connectivity patterns, with autism showing weaker connections and ADHD showing stronger connections in certain brain regions, which could influence future diagnostics and treatments.