Scientists at USC are testing a tiny stem cell-based retinal implant in a phase 2b clinical trial to potentially restore vision in patients with advanced dry age-related macular degeneration, building on earlier promising safety and efficacy results.
Chinese researchers have developed a new scalable and cost-effective method to produce engineered natural killer cells from cord blood stem cells, enhancing cancer immunotherapy potential by improving efficiency and reducing costs, with successful tumor-killing activity demonstrated in preclinical models.
A new study suggests a link between grey hair and cancer risk, indicating that the process of hair greying, driven by stress and DNA damage in melanocyte stem cells, may be a protective response to prevent harmful mutations that could lead to cancer, although bypassing this mechanism might increase melanoma risk.
Scientists have discovered that a protein called platelet factor 4 can reverse aging-related decline in blood and immune stem cells, offering a promising strategy to combat age-related immune system weakening by restoring youthful function to these cells.
Research suggests that gray hair in mice indicates a natural process of eliminating DNA-damaged cells, which may protect against cancer, though carcinogens can hijack this system to promote cell survival and potentially lead to melanoma; similar mechanisms may exist in humans, highlighting a complex relationship between aging, hair graying, and cancer risk.
Scientists have created the most detailed maps of how human and mouse brains develop from stem cells into neurons, providing new insights into brain differentiation and potential implications for neurological conditions, as part of the BRAIN Initiative.
Scientists discovered that certain flatworms can naturally develop two heads and reverse their body axis without impairing their survival or reproduction, thanks to their remarkable regenerative abilities and pluripotent stem cells, revealing extreme physiological flexibility.
A Japanese study suggests that gray hair may be a sign of the body's natural defense mechanism against skin cancer, specifically melanoma, by promoting the differentiation and loss of melanocyte stem cells in response to DNA damage, thereby reducing the risk of tumor development.
Scientists have discovered that DNA damage in melanocyte stem cells can lead to hair graying through senescence, but in the presence of carcinogens, these cells avoid this process and expand, increasing cancer risk. The study links the biological pathways of aging, hair color change, and cancer development, highlighting how stem cell stress responses can diverge into either protective exhaustion or dangerous expansion, with implications for understanding melanoma and aging.
Harvard researchers discovered that axolotls use their 'fight or flight' sympathetic nervous system, particularly adrenaline signaling, to activate stem cells body-wide for limb regeneration, a process that could inform future human regenerative medicine.
Researchers at King's College London have made significant progress in growing lab-based human teeth using innovative scaffolds and cell interactions, aiming to develop biological replacements that could be more natural and accepted by the body than current implants. While challenges remain, this research paves the way for future dental treatments that could fully regenerate teeth from a patient's own cells within the next decade.
Scientists at Cedars-Sinai developed lab-created young immune cells from human stem cells that reversed signs of aging and Alzheimer's in mice, showing potential for future human therapies to improve brain health and memory.
MIT research shows that dietary cysteine can activate immune signaling to promote intestinal regeneration, potentially aiding recovery from radiation and chemotherapy damage, with implications for human health and tissue repair.
Research suggests that hair graying may be linked to a natural defense mechanism against cancer, with stem cells in hair follicles responding to DNA damage by either differentiating and causing graying or avoiding differentiation to prevent tumor formation, based on a mouse study. However, further research is needed to understand implications for humans.
A study suggests that the process of hair turning gray is linked to how pigment-producing stem cells respond to stress, with damaged cells either dying off or surviving and potentially turning into melanoma, highlighting a biological trade-off between aging and cancer risk.