Tag

Stem Cells

All articles tagged with #stem cells

health-and-medicine5 days ago•5 min saved

Lab-grown dopamine cells aim to reboot movement in Parkinson’s patients

Researchers are testing implanted induced pluripotent stem cells engineered to become dopamine-producing neurons in the brains of Parkinson’s patients in a Phase 1 trial. Delivered via MRI-guided surgery into the basal ganglia, the goal is to restore dopamine production, improve motor function, and slow disease progression. The 12-person study (RNDP-001) is monitored for 12–15 months with long-term follow-up planned for up to five years to assess safety (e.g., dyskinesia, infection) and efficacy, and it has FDA fast-track designation.

via ScienceDaily|

#clinical-trial #dopamine #health-and-medicine

science17 days ago•9 min saved

Serine Shortage Reprograms Hair Follicle Stem Cells for Faster Wound Healing

Rockefeller University researchers found that when serine levels drop, the integrated stress response activates and hair follicle stem cells reduce hair production to prioritize skin repair, speeding wound healing; boosting serine has limited effect due to the body's tight control over its circulation, though restoring serine in cells lacking it can partly rescue hair growth—pointing to diet or drug strategies to modulate serine/ISR for faster healing.

via SciTechDaily|

#biology #metabolism #science

science19 days ago•3 min saved

Rete ridges: unlocking skin regeneration to turn back the clock

Researchers compared skin ridges across multiple mammals to uncover how rete ridges form, with findings suggesting these structures may harbor stem cells essential for regeneration and could pave the way for anti-aging skin therapies.

via Nature|

#regenerative-medicine #rete-ridges #science

science22 days ago•4 min saved

Young-Microbial Boost Rejuvenates Aging Mouse Guts

Transplanting fecal material from young to old mice increased intestinal stem cell activity and Wnt signaling, speeding gut tissue renewal and improving radiation healing, suggesting gut microbes can influence age-related intestinal decline (human relevance to be studied).

via ScienceAlert|

#aging #akkermansia #gut-health

science24 days ago•5 min saved

Tiny Sea Anemone Holds Clues to Reversing Aging

A study of the scarlet sea anemone, Nematostella vectensis, identifies tiny multipotent stem cells and key genes that drive its remarkable regeneration and aging resistance, using single-cell genomics and CRISPR to link nanos2 and piwi to somatic cell fate, making it a powerful model for anti-aging research while noting that translating these findings to humans remains a challenge.

via Indian Defence Review|

#aging #cnidaria #nematostella-vectensis

health1 month ago•55 min saved

Stem-cell derived 'pain sponge' targets pain at the source in arthritis

Researchers engineered human pluripotent stem cell–derived sensory neurons that act as a biological "pain sponge," soaking up inflammatory pain signals at the site of inflammation in mice with osteoarthritis and also promoting bone and cartilage repair. The SN101 approach is in preclinical stages, with safety, immune response and translation to humans unresolved and no peer‑reviewed human data yet.

via Live Science|

#health #neuroscience #osteoarthritis

science1 month ago•5 min saved

Notch Timing Unlocks Lab-Grown Helper and Killer T Cells for Off-the-Shelf Immunotherapy

UBC researchers show that precisely tuning the duration and intensity of Notch signaling in stem cells can reliably steer them to become helper or killer T cells, enabling scalable, off-the-shelf immunotherapies for cancer and other diseases. This overcomes a long-standing bottleneck by producing both T cell types from renewable sources, potentially reducing manufacturing costs and time.

via Indian Defence Review|

#immunotherapy #notch-signaling #off-the-shelf

health1 month ago•10 min saved

LeAnn Rimes Opens Up About Plasma Exchange After On‑Stage Dental Incident

LeAnn Rimes revealed on Instagram that she underwent Therapeutic Plasma Exchange, a procedure that removes plasma and replaces it with albumin, plus a stem cell boost. She documented the treatment after months of dealing with a dental emergency on stage and said she shares her health experiences to inform others, noting she experienced a headache after the stem cell push.

via TV Insider|

#dental-emergency #health #health-journey

health1 month ago•4 min saved

Breakthrough Retina Implant Shows Promise in Restoring Sight

Scientists at USC are testing a tiny stem cell-based retinal implant in a phase 2b clinical trial to potentially restore vision in patients with advanced dry age-related macular degeneration, building on earlier promising safety and efficacy results.

via ScienceDaily|

#clinical-trial #health #macular-degeneration

science1 month ago•3 min saved

Scientists Develop Method to Mass-Produce Cancer-Fighting Natural Killer Cells

Chinese researchers have developed a new scalable and cost-effective method to produce engineered natural killer cells from cord blood stem cells, enhancing cancer immunotherapy potential by improving efficiency and reducing costs, with successful tumor-killing activity demonstrated in preclinical models.

via SciTechDaily|

#cancer-immunotherapy #cancer-treatment #car-nk-therapy

health1 month ago•2 min saved

Study Reveals Potential Link Between Grey Hair and Cancer

A new study suggests a link between grey hair and cancer risk, indicating that the process of hair greying, driven by stress and DNA damage in melanocyte stem cells, may be a protective response to prevent harmful mutations that could lead to cancer, although bypassing this mechanism might increase melanoma risk.

via tyla.com|

#cancer #grey-hair #health

science2 months ago•3 min saved

Innovative Approaches to Rejuvenate the Aging Immune System

Scientists have discovered that a protein called platelet factor 4 can reverse aging-related decline in blood and immune stem cells, offering a promising strategy to combat age-related immune system weakening by restoring youthful function to these cells.

via SciTechDaily|

#aging #immune-system #platelet-factor-4

science3 months ago•13 min saved

Gray Hair May Offer Unexpected Cancer Protection, Study Finds

Research suggests that gray hair in mice indicates a natural process of eliminating DNA-damaged cells, which may protect against cancer, though carcinogens can hijack this system to promote cell survival and potentially lead to melanoma; similar mechanisms may exist in humans, highlighting a complex relationship between aging, hair graying, and cancer risk.

via StudyFinds|

#cancer-prevention #gray-hair #kit-ligand

science3 months ago•3 min saved

Revolutionary Brain Atlases Illuminate Development and Disease

Scientists have created the most detailed maps of how human and mouse brains develop from stem cells into neurons, providing new insights into brain differentiation and potential implications for neurological conditions, as part of the BRAIN Initiative.

via Nature|

#atlas #brain-development #embryonic-development

science4 months ago•3 min saved

Two-Headed Flatworms Generate Unusual Offspring, Scientists Find

Scientists discovered that certain flatworms can naturally develop two heads and reverse their body axis without impairing their survival or reproduction, thanks to their remarkable regenerative abilities and pluripotent stem cells, revealing extreme physiological flexibility.

via ScienceAlert|

#body-axis-reversal #flatworms #regeneration