Tag

Regenerative Medicine

All articles tagged with #regenerative medicine

science7 days ago•7 min saved

Molecular Switch Could Unlock Lungs' Self-Healing, Mayo Study Finds

Mayo Clinic researchers uncovered a molecular circuit that decides whether alveolar type 2 (AT2) lung cells repair tissue or defend against infection; a clamp-like regulator, C/EBPα, must be released after injury, with PRC2 and DLK1 timing the switch. The finding explains why infections slow lung healing and suggests regenerative therapies that modulate C/EBPα or reprogram AT2 cells, potentially enabling cell replacement. Published in Nature Communications (2025), the work also points to early-detection biomarkers and ties to Mayo's Precure and Genesis initiatives.

via SciTechDaily|

#at2-cells #cebpa #lung

science19 days ago•3 min saved

Rete ridges: unlocking skin regeneration to turn back the clock

Researchers compared skin ridges across multiple mammals to uncover how rete ridges form, with findings suggesting these structures may harbor stem cells essential for regeneration and could pave the way for anti-aging skin therapies.

via Nature|

#regenerative-medicine #rete-ridges #science

science20 days ago•5 min saved

Blocking an Aging Enzyme Sparks Cartilage Regrowth Without Stem Cells

Scientists inhibited the aging-associated enzyme 15-PGDH in aged mice with cartilage damage, triggering regeneration of hyaline cartilage without stem cells and showing early repair signals in human cartilage samples; if these findings translate to humans, treatments for osteoarthritis could shift toward direct cartilage restoration rather than surgery, though safety and clinical trials are still needed.

via NCHStats|

#15-pgdh-enzyme #cartilage-regeneration #hyaline-cartilage

science22 days ago•7 min saved

DMTF1: A Molecular Switch to Rejuvenate Aging Brain Cells

Researchers have identified the transcription factor DMTF1 as a key regulator that preserves neural stem cell activity in aging brains. In aging models with telomere damage, DMTF1 levels drop and neural stem cell regeneration declines; reactivating DMTF1 restores regenerative capacity and reveals its role in activating helper genes that open chromatin for growth-related genes. This suggests potential therapies to slow cognitive aging by boosting neural stem cell function, though most work so far is in vitro, with the long-term aim of developing small molecules to safely enhance DMTF1 without increasing brain tumor risk.

via SciTechDaily|

#brain-aging #dmtf1 #neural-stem-cells

science1 month ago•2 min saved

New Research Finds Regeneration in Human Heart Cells After Attack

Researchers analyzing living human heart tissue found that heart muscle cells can divide after a heart attack, indicating potential regeneration in humans. By examining tissue from a donor heart and bypass patients and using RNA sequencing, they identified conditions that promote cardiomyocyte division. While promising, the findings do not yet prevent scar formation or heart damage, but could guide future regenerative therapies, and were published in Circulation Research.

via ScienceAlert|

#cardiomyocytes #circulation-research #heart-attack

science1 month ago•7 min saved

Dancing-molecule nanotherapy crosses the blood-brain barrier to repair stroke damage

Northwestern researchers have developed an injectable regenerative nanomaterial built from dynamic “dancing molecules” that can cross the blood-brain barrier after reperfusion in a mouse model of ischemic stroke. Delivered intravenously immediately after clot removal, the therapy reduced brain damage and inflammation without observed toxicity, suggesting it could complement clot-busting treatments. The approach relies on smaller peptide assemblies crossing the BBB before larger nanofibers form in brain tissue, and may have implications for traumatic brain injury and neurodegenerative diseases. Next steps include longer-term functional studies and exploring additional regenerative signals.

via SciTechDaily|

#blood-brain-barrier #nanomedicine #regenerative-medicine

health3 months ago•2 min saved

Scientists Discover Heart's Natural Ability to Heal and Regenerate

Scientists at Mount Sinai have discovered that reactivating the Cyclin A2 (CCNA2) gene in adult hearts can promote self-healing after injuries like heart attacks, potentially revolutionizing treatment by enabling natural heart regeneration and reducing reliance on transplants or mechanical devices.

via Times of India|

#ccna2 #gene-therapy #health

science4 months ago•1 min saved

Lab-Grown Embryo Models Pave the Way for Blood Cell Production and Donation Solutions

Researchers at the University of Cambridge have developed embryo-like structures called hematoids from donated human stem cells that can produce red and white blood cells in the lab, potentially supplementing blood donations and advancing treatments for blood disorders. These structures mimic early human blood development and are more self-sustaining than previous methods, marking a significant step toward regenerative therapies.

via ScienceAlert|

#blood-disorders #blood-stem-cells #hematoids

science4 months ago•4 min saved

Breakthrough in Lab-Grown Blood Cell Production Promises Advances in Regenerative Medicine

Researchers at the University of Cambridge have developed a lab-created embryo-like structure called 'hematoids' that can produce human blood cells, mimicking early embryonic blood development, with potential applications in understanding blood disorders and regenerative therapies.

via University of Cambridge|

#blood-cells #early-human-development #hematoids

science4 months ago•2 min saved

Advances in Lab-Grown Blood and Heart Cells for Regenerative Medicine

Scientists have created embryo-like structures from stem cells in the lab that can produce human blood cells, opening new avenues for regenerative medicine and understanding early human development, with potential applications in treating blood disorders and customizing therapies using a patient's own cells.

via The Guardian|

#blood-cells #human-development #lab-grown-embryo

science4 months ago•2 min saved

Nobel Laureate John Gurdon, Pioneer in Cloning Research, Dies at 92

John B. Gurdon, a Nobel laureate whose pioneering work in cell manipulation led to the first cloning of a mammal, Dolly the sheep, and laid the groundwork for stem cell and regenerative medicine, died at age 92.

via The New York Times|

#cell-manipulation #cloning #nobel-prize

health5 months ago•4 min saved

Scientists Discover Potential Cure for Baldness

Scientists have developed a new drug, PP405, that reactivates dormant hair follicles by increasing lactate levels, showing promise as a potential cure for baldness. The drug has passed safety trials and is set to undergo effectiveness testing next year, offering a different approach from current treatments by actively promoting hair growth rather than just slowing loss.

via Men's Health|

#hair-follicle #hair-loss #health

health5 months ago•2 min saved

Revolutionary 3D-Printed Scaffolds Enable Spinal Cord Regeneration in Rats

Researchers at the University of Minnesota have developed a 3D-printed scaffold populated with stem cells that successfully regrows nerve fibers and restores function in rats with severed spinal cords, offering promising potential for future spinal injury treatments.

via Good News Network|

#3d-printing #health #neural-regeneration

science6 months ago•2 min saved

3D Printing and Stem Cells Show Promise in Spinal Cord Repair

Researchers at the University of Minnesota have developed a groundbreaking method using 3D-printed scaffolds and stem cells to repair spinal cord injuries in rats, leading to nerve regeneration and functional recovery, offering hope for future clinical applications.

via ScienceDaily|

#3d-printing #neural-regeneration #regenerative-medicine

health6 months ago•1 min saved

Israeli hospital pioneers lab-grown kidneys lasting 34 weeks

An Israeli hospital, in collaboration with Tel Aviv University, has developed a lab-grown kidney organoid that survived for over 34 weeks, marking a significant advancement in regenerative medicine and offering potential for modeling kidney disease and repairing injured kidneys, though clinical application will require more research.

via Times of India|

#health #kidney-disease #lab-grown-kidneys