
Childhood Junk Food Rewires Appetite Center, Gut Bacteria Offer Reset
In a mouse study, early-life exposure to a high-fat, high-sugar diet permanently shifts hypothalamic appetite pathways and adult feeding behavior even after weight normalizes; however, interventions targeting the gut microbiome—probiotic Bifidobacterium longum APC1472 or prebiotic fibers FOS/GOS—can restore brain–gut signaling and mitigate these long-term effects, with some sex-specific vulnerabilities observed.












