
Antibiotics Are the Biggest Gut Microbiome Disruptors, but Other Meds Matter
Gastroenterologists say antibiotics cause the most disruption to the gut microbiome, but other medications—including proton pump inhibitors, laxatives, NSAIDs, and certain cardiac drugs—can also alter gut bacteria, with some changes lasting years after stopping. Probiotics aren’t reliably regulated or proven to protect the microbiome, though Saccharomyces boulardii may reduce the risk of C. difficile diarrhea. If you must take such meds, focus on fiber-rich foods to support gut health and discuss qualquer protective steps with your doctor.













