Tag

Amyloidosis

All articles tagged with #amyloidosis

medicine8 days ago•6 min saved

Pomegranate Leaves Yield Molecule That Dismantles TTR Amyloid Fibrils

Researchers at Kumamoto University identified 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG) from pomegranate leaves and branches that selectively dismantles preexisting transthyretin (TTR) amyloid fibrils in vitro, in vivo, and with patient-derived fibrils ex vivo, reducing deposits and improving healthspan and lifespan in a C. elegans model. Unlike amyloid-β, PGG targets TTR aggregates specifically, suggesting a promising natural lead for treating TTR amyloidosis, though safety and efficacy in humans remain to be established.

via SciTechDaily|

#amyloidosis #medicine #natural-product

health5 months ago•2 min saved

Cardiologist Uncovers Unexpected Cause of Heart Failure

A cardiologist highlights cardiac amyloidosis, a rare but underdiagnosed condition where misfolded proteins build up in the heart, causing stiffness and failure, often mistaken for common issues like hypertension or aging.

via The Times of India|

#amyloidosis #cardiac-amyloidosis #health

wildlife-conservation2 years ago•3 min saved

"Study Reveals Alarming Inbreeding Rates in Adorable but Deadly Wildcat"

A study has found that black-footed cats, the smallest and deadliest cats in Africa, are facing alarming levels of inbreeding due to genetic isolation caused by habitat fragmentation. This inbreeding increases the risk of developing amyloidosis, a rare and deadly disease that affects about 70% of the captive black-footed cat population. The researchers identified harmful gene variants associated with amyloidosis and emphasized the need for more conservation efforts and research on small feline species.

via Yahoo Life|

#amyloidosis #black-footed-cats #genetic-isolation

health2 years ago•5 min saved

Men Overcome "Incurable" Heart Failure in Medical Miracle.

Three elderly men diagnosed with an until-now irreversible heart condition, transthyretin cardiac amyloidosis, experienced an unprecedented spontaneous recovery confirmed by medical scans, leading researchers at UCL and the Royal Free Hospital to identify a unique amyloid-targeting immune response in these patients. The researchers found evidence of an immune response in the three men that specifically targeted amyloid. The amyloid-targeting antibodies were not found in other patients whose condition progressed as normal.

via SciTechDaily|

#amyloidosis #antibodies #gene-editing

health2 years ago•4 min saved

Breakthrough Study Shows Reversal of Incurable Heart Disease

Three patients with transthyretin cardiac amyloidopathy (ATTR-CM), a rare and progressive heart condition, have spontaneously recovered from the disorder, according to scientists from University College London. The researchers believe that the recovery may have been due to an immune response, suggesting that antibody treatments could be effective against the condition. The findings may lead to new treatments and possibly even a cure for the condition, which currently has no therapy that can reverse it.

via Medical News Today|

#amyloidosis #antibody-treatments #health

health2 years ago•4 min saved

Study shows reversal of devastating heart condition.

Three men with heart failure caused by amyloidosis, a progressive and previously irreversible condition, have recovered after their condition spontaneously reversed, according to a study by UCL and the Royal Free Hospital. The researchers found evidence of an immune response in the three men that specifically targeted amyloid, suggesting that amyloid-targeting antibodies could be recreated in a lab and used as a therapy. Current treatments aim to relieve symptoms of heart failure, but do not tackle the amyloid. The study raises the bar for what might be possible with new treatments.

via Medical Xpress|

#amyloidosis #antibodies #health