Alzheimer’s Reimagined as an Immune-System Brain Disorder

The piece argues Alzheimer's may be primarily an autoimmune disorder of the brain rather than just a brain disease, challenging the traditional beta-amyloid focus and the controversial aducanumab approval. It posits beta-amyloid may be part of the brain’s immune response that goes awry, driving dementia, while other theories (mitochondrial dysfunction, infections, metal handling) gain traction. With Alzheimer's affecting tens of millions worldwide, the article calls for new immune- and mechanism-based therapies and directions.