Tag

Clinicaltrials

All articles tagged with #clinicaltrials

health1 month ago•6 min saved

Mice Reversal of Advanced Alzheimer's Sparks Hope for Humans

A study from University Hospitals, Case Western Reserve University, and the Cleveland VA reversed advanced Alzheimer's in mice by stabilizing brain NAD+ energy balance with the compound P7C3-A20, achieving full cognitive recovery and suggesting a potential amyloid-independent therapy for humans. While promising, results in animals don’t guarantee human success; the team aims for phase I safety trials within about 18 months and envisions broader use for neurodegeneration, alongside lifestyle measures and caregiver support.

via WKYC|

#alzheimers #clinicaltrials #health

health6 months ago•4 min saved

New Dual-Action Weight Loss and Diabetes Drug Outperforms Current Treatments

A new drug called ecnoglutide shows promise as a treatment for type 2 diabetes and weight loss, potentially rivaling Ozempic, with clinical trials indicating it may be more effective in lowering blood sugar and promoting weight loss than dulaglutide, and similar or better than semaglutide, though it is not yet approved for market.

via Newsweek|

#clinicaltrials #diabetes #ecnoglutide

health6 months ago•9 min saved

Lilly's Orforglipron Shows Promise in Obesity Treatment Despite Investor Concerns

Eli Lilly's obesity pill, orforglipron, despite underwhelming trial data compared to Novo Nordisk's oral semaglutide, remains a competitive option due to its potential advantages in manufacturing, cost, and ease of use, with market predictions favoring Lilly's larger global rollout and market share in the future.

via CNBC|

#clinicaltrials #elililly #health

health6 months ago•2 min saved

Research Reveals Mixed Effects of Semaglutides on Muscle Strength and Size

A study on mice suggests that weight loss drugs like Ozempic and Wegovy may cause loss of lean mass, including organs like the liver and some muscles, raising concerns about potential impacts on muscle strength and organ health in humans, especially older adults. Further research is needed to confirm these effects in humans and assess health risks.

via NewsNation|

#clinicaltrials #health #muscleloss

health8 months ago•2 min saved

Obesity Injections Show Reduced Effectiveness in Real-World Settings

A study in the US suggests that anti-obesity injections like semaglutide and tirzepatide have less impact on weight loss in real-world settings compared to clinical trials, mainly due to higher discontinuation rates and lower maintenance doses, with factors such as cost, side effects, and medication shortages influencing adherence.

via NDTV|

#clinicaltrials #health #injectables

health1 year ago•3 min saved

Mushroom Extract: A New Ally in Prostate Cancer Fight

Researchers at the City of Hope have found that white button mushroom extract may slow or prevent prostate cancer growth by reducing myeloid-derived suppressor cells, which suppress the immune response. Early trials in mice and humans show promising results, suggesting the extract could enhance anti-cancer immune defenses when used alongside traditional treatments. While the exact mechanism is unknown, the study supports the potential of 'food as medicine' in cancer care. The findings were published in Clinical and Translational Medicine.

via ScienceAlert|

#cancerresearch #clinicaltrials #health

health1 year ago

Amgen's Obesity Drug Achieves 20% Weight Loss, Yet Shares Fall

Early data from clinical trials indicate that the new obesity drug MariTide can help patients lose up to 20% of their body weight, offering a promising new treatment option for weight management.

via The New York Times|

#clinicaltrials #health #maritide

health1 year ago•2 min saved

Study Links Weight-Loss Drugs to Enhanced Kidney Health

A study published in the Lancet Diabetes & Endocrinology journal reveals that weight-loss drugs, specifically GLP-1 receptor agonists, can significantly improve kidney health by reducing the risk of kidney failure and worsening kidney function by up to 22%. The meta-analysis of 11 clinical trials involving over 85,000 participants also confirmed cardiovascular benefits, with a 14% reduction in cardiovascular events. These findings suggest that GLP-1 receptor agonists could play a crucial role in managing chronic kidney disease and cardiovascular conditions, potentially influencing future clinical guidelines.

via The Guardian|

#chronicdiseases #clinicaltrials #glp1receptoragonists

business1 year ago•1 min saved

Cassava Sciences' Stock Crashes After Alzheimer's Drug Fails Phase 3 Trials

Cassava Sciences' stock plummeted by 80% in premarket trading after its Alzheimer's drug, Simufilam, failed to show significant efficacy in a late-stage trial. The company announced it would discontinue further studies of the drug, which was intended for mild-to-moderate Alzheimer's patients. This setback follows a $40 million settlement with the SEC over allegations of clinical trial data manipulation.

via Investopedia|

#alzheimersdisease #business #cassavasciences

business1 year ago•0 min saved

Viking Therapeutics Faces Market Challenges Despite Promising Obesity Pill Data

Viking Therapeutics presented promising data on their oral obesity treatment, but the market reaction was unexpectedly negative. Despite analysts finding the data compelling, the company's stock did not see the anticipated increase. Viking is now preparing for Phase 3 trials, aiming to further validate their treatment's efficacy.

via Endpoints News|

#business #clinicaltrials #obesity

business1 year ago•1 min saved

Viking Therapeutics Faces Setback Amid Obesity Drug Competition

Viking Therapeutics' stock fell by about 11% after announcing trial results for its weight-loss drugs, despite showing a placebo-adjusted average weight loss of up to 6.8% in the oral version. Analysts expressed concerns over the high costs and challenges of scaling production for both oral and injectable forms, suggesting that established companies like Eli Lilly and Novo Nordisk have significant competitive advantages. Viking's shares have seen substantial gains this year, but the path to market remains long and costly.

via Investopedia|

#business #clinicaltrials #obesitydrug

health-and-medicine2 years ago•3 min saved

"Ibogaine: A Promising Psychedelic for Healing Traumatic Brain Injury and PTSD"

A small study has shown that a single dose of the psychedelic drug ibogaine, combined with magnesium, significantly improved symptoms of depression, anxiety, PTSD, and cognitive functions in military veterans with traumatic brain injuries (TBIs). The research, which involved 30 special ops veterans, suggests that ibogaine may interact with various neurotransmitter systems and support brain cell growth and rewiring. Despite ibogaine being a Schedule I controlled substance in the U.S., the positive findings from the study, published in Nature Medicine, indicate the need for larger, double-blind, placebo-controlled clinical trials to further investigate its potential as a therapeutic drug for TBI and other neuropsychiatric conditions.

via Gizmodo|

##clinicaltrials #health-and-medicine

health-and-medicine2 years ago•0 min saved

"Allogene Shifts Gears with New Strategy and Partnerships in Cell Therapy for Blood Cancer Amid Workforce Reduction"

Allogene Therapeutics is altering its development strategy for ALLO-501A, an off-the-shelf cell therapy for blood cancer, due to intense competition from personalized CAR-T treatments. The company is discontinuing two ongoing clinical trials for patients with advanced-stage lymphoma and instead will initiate a new study targeting newly diagnosed high-risk lymphoma patients. This shift aims to position ALLO-501A more effectively in the competitive blood cancer treatment landscape.

via STAT|

##allogenetherapeutics #bloodcancer

health-and-medicine2 years ago•3 min saved

"The Future of Obesity Treatment: Exploring the Broad Impact of New Weight-Loss Drugs"

Weight-loss drugs containing semaglutide, like Novo Nordisk's Ozempic and Lilly's Mounjaro, are being explored for their potential benefits in treating a variety of health conditions beyond type 2 diabetes. These include chronic kidney disease, cardiovascular disease, neurological disorders such as Alzheimer's and Parkinson's, liver disease, sleep apnea, polycystic ovary syndrome (PCOS), knee osteoarthritis, and even alcohol addiction. The drugs are part of a class known as GLP-1 therapies, which are currently undergoing various stages of clinical trials to determine their efficacy in these new applications.

via Reuters|

##chronicdiseases #clinicaltrials

health2 years ago•3 min saved

New Evidence Shows Medication Can Reverse Multiple Sclerosis.

Researchers have developed a technique to measure the effectiveness of clemastine, an over-the-counter antihistamine, in repairing the brain of patients with multiple sclerosis (MS). Using MRI scans, they found that patients treated with clemastine experienced modest increases in myelin water, indicating myelin repair. The myelin water fraction technique could be used to track myelin recovery and set the standard for future research into remyelinating therapies. Clemastine works by stimulating the differentiation of myelin-making stem cells, making it a generation ahead of existing MS drugs. Future research will examine clemastine's potential in treating brain injury in premature infants.

via Medical Xpress|

#brainbiomarker #clinicaltrials #health