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Cystatin C

All articles tagged with #cystatin c

science1 month ago•6 min saved

Cancer Signals Could Help the Brain Fight Alzheimer's, Mouse Study Finds

A mouse study shows tumors releasing cystatin-C into the bloodstream can cross the blood-brain barrier, bind amyloid-beta, and activate microglia via Trem2 to clear plaques, sometimes improving memory in Alzheimer’s-like mice. While intriguing, these results are in animals and it's unknown whether humans would experience a similar protective effect; researchers are exploring therapies that mimic this mechanism without cancer.

via ScienceAlert|

#alzheimers-disease #amyloid-beta #cancer

science1 month ago•11 min saved

Tumor-released cystatin-C may help clear Alzheimer's plaques in mice

A mouse study found that human tumors implanted in Alzheimer’s-model mice released cystatin-C into the bloodstream, which crossed the blood–brain barrier and bound to amyloid-beta plaques. This activated brain microglia via Trem2, boosting plaque clearance and sometimes improving memory. While intriguing as a potential pathway to treat or prevent Alzheimer’s, the findings are in mice and may not translate to humans, where cancer and Alzheimer's have a complex, inverse epidemiological relationship. Future work may explore therapies that mimic cystatin-C’s beneficial effects without cancer.

via The Conversation|

#alzheimers-disease #amyloid-beta #cancer

science1 month ago•2 min saved

Cancer Protein May Unlock a New Avenue for Alzheimer’s Treatment

In a mouse study, tumors produced the protein cystatin-C, which traveled to the brain, bound toxic amyloid oligomers, and activated microglia via the TREM2 receptor to clear plaques, improving cognitive tasks. While promising as a novel research path beyond amyloid-lowering strategies, whether these effects translate to humans remains unknown and more work is needed; the study warns against pursuing cancer as a therapy and emphasizes early-stage findings.

via Gizmodo|

#alzheimers #cancer #cystatin-c

science1 month ago•5 min saved

Cancer-produced protein dissolves Alzheimer’s plaques in mice, hinting at new treatments

A Cell study (15 years in the making) finds that a protein called cystatin C, produced by cancer cells, can cross the blood–brain barrier and help break apart amyloid plaques in mouse models of Alzheimer’s disease, offering a possible explanation for the observed link between cancer and lower Alzheimer’s risk and suggesting a new avenue for drug development—though the findings are preclinical and in animals.

via Nature|

#alzheimers-disease #amyloid-plaques #blood-brain-barrier

health1 month ago•5 min saved

Blood Test Mismatch Could Predict Major Health Risks

A global study finds that discrepancies between creatinine and cystatin C blood tests, used to assess kidney health, can predict higher risks of kidney failure, heart disease, and death, emphasizing the importance of using both tests together for accurate diagnosis and early intervention.

via SciTechDaily|

#blood-tests #creatinine #cystatin-c

health3 months ago•2 min saved

Top Doctor Shares 4 Easy Tests for Early Kidney Disease Detection

Kidney diseases are increasing rapidly, and early detection through simple tests like eGFR, Cystatin C, urine dipstick, and protein-to-creatinine ratio is crucial for effective treatment. Regular screening can help identify silent issues before they worsen, and consulting a nephrologist is recommended if abnormalities are found.

via The Times of India|

#cystatin-c #early-detection #egfr

health3 months ago•4 min saved

Discrepancies in Kidney Tests Signal Higher Health Risks

A study shows that discrepancies between creatinine and cystatin C tests for kidney function can predict higher risks of kidney failure, heart disease, and death, emphasizing the importance of using both tests for better diagnosis and early intervention.

via Medical Xpress|

#creatinine #cystatin-c #early-detection