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Tau Protein

All articles tagged with #tau protein

Blood tau clock could forecast when Alzheimer’s symptoms begin
health6 days ago

Blood tau clock could forecast when Alzheimer’s symptoms begin

A Nature Medicine study describes a blood test that detects an abnormal form of tau in the blood, which may serve as a molecular clock to predict not only if someone will develop Alzheimer’s but also when symptoms could start. If validated in larger trials, it could enable earlier interventions and streamline clinical testing for therapies, though experts caution that it’s not yet recommended for cognitively unimpaired individuals to use this biomarker outside of research.

via Nature|
#alzheimers-disease#biomarker#blood-test
Dissolving Tau Precursor Clusters Could Stop Alzheimer’s
science24 days ago

Dissolving Tau Precursor Clusters Could Stop Alzheimer’s

Researchers at Tokyo Metropolitan University found that tau proteins first assemble into reversible precursor clusters before forming harmful fibrils in Alzheimer's disease. By applying polymer-physics concepts and tweaking salt levels in the presence of heparin, they dissolved these clusters, preventing fibril formation. This suggests a new therapeutic direction focused on the early, reversible tau clusters rather than mature fibrils, with potential implications for other neurodegenerative diseases.

via SciTechDaily|
#alzheimers-disease#fibrils#polymer-physics
New Study Suggests Enzyme Blockade Could Reverse Alzheimer's
health1 year ago

New Study Suggests Enzyme Blockade Could Reverse Alzheimer's

A study published in Nature Neuroscience has identified the enzyme tyrosine kinase 2 (TYK2) as a potential target for treating Alzheimer's disease. In genetically modified mice with excessive tau protein, blocking TYK2 reduced harmful tau buildup and showed signs of neuronal recovery. This discovery could lead to new drug development, although further research is needed to confirm these findings in humans.

via SILive.com|
#alzheimers#drug-development#enzyme
New Insights into Enzymes and Tau Proteins in Alzheimer's Disease
health1 year ago

New Insights into Enzymes and Tau Proteins in Alzheimer's Disease

A new study suggests that blocking the enzyme tyrosine kinase 2 (TYK2) may help reduce the toxic buildup of tau protein in the brain, a key feature of Alzheimer's disease. Researchers found that TYK2 adds a tag to tau, making it difficult for the brain to clear, leading to neurofibrillary tangles. By inhibiting TYK2 in mice, the study showed a reduction in harmful tau and signs of neuronal recovery, indicating potential for new Alzheimer's treatments. However, further research is needed to confirm these findings in humans.

via ScienceAlert|
#alzheimers#drug-development#health
"Human Neuron Model Unlocks Potential Breakthrough in Alzheimer's Treatment"
health-science1 year ago

"Human Neuron Model Unlocks Potential Breakthrough in Alzheimer's Treatment"

Scientists at Weill Cornell Medicine have developed a human neuron model that simulates the spread of tau protein aggregates in the brain, shedding light on potential drug targets to block this process. Using CRISPR/Cas9 technology, the researchers created a neuron model with diseased forms of tau, allowing them to observe tau spread within weeks. Through CRISPRi screening, they identified 500 genes that impact tau abundance, including the UFMylation cascade, which, when altered, could block tau propagation. This finding was validated in both human neurons and mouse models, offering new directions for the development of treatments for Alzheimer’s disease and related conditions.

via PsyPost|
#alzheimers-research#crisprcas9-technology#health-science
"Breakthrough Blood Test for Early Alzheimer's Detection"
health2 years ago

"Breakthrough Blood Test for Early Alzheimer's Detection"

A new study published in JAMA Neurology suggests that a blood test screening for Alzheimer's disease may be effective in detecting changes in amyloid beta and tau protein levels in the brain years before symptoms appear. The test, developed by a company called AD-Detect, was found to accurately identify abnormal levels of amyloid beta and tau in 80% of tested participants, potentially allowing for early intervention with emerging pharmaceutical treatments designed to reduce amyloid buildup. However, some experts caution that blood biomarkers may not have a clinical role in evaluating patients with memory loss and dementia, and using them for diagnosis could lead to overdiagnosis and unnecessary treatment.

via Medical News Today|
#alzheimers-disease#blood-test#brain-changes
Genetic anomaly reveals potential Alzheimer's prevention clues
health2 years ago

Genetic anomaly reveals potential Alzheimer's prevention clues

A woman from a Colombian family with a history of early-onset Alzheimer's disease managed to evade the disease despite carrying the genetic defect. Researchers have discovered that she carried a rare variant of the APOE gene known as the Christchurch mutation, which severed the link between the early phase of Alzheimer's (amyloid beta buildup) and the late phase (tau protein accumulation). This finding suggests a new approach to preventing Alzheimer's dementia by mimicking the effects of the APOE Christchurch mutation to halt the progression of the disease.

via Medical Xpress|
#alzheimers-disease#amyloid-beta#apoe-gene