"Human Neuron Model Unlocks Potential Breakthrough in Alzheimer's Treatment"

Scientists at Weill Cornell Medicine have developed a human neuron model that simulates the spread of tau protein aggregates in the brain, shedding light on potential drug targets to block this process. Using CRISPR/Cas9 technology, the researchers created a neuron model with diseased forms of tau, allowing them to observe tau spread within weeks. Through CRISPRi screening, they identified 500 genes that impact tau abundance, including the UFMylation cascade, which, when altered, could block tau propagation. This finding was validated in both human neurons and mouse models, offering new directions for the development of treatments for Alzheimer’s disease and related conditions.