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Mutations

All articles tagged with #mutations

Mewgenics Delivers Deep, Cat-Centered Roguelite Chaos
gaming19 days ago

Mewgenics Delivers Deep, Cat-Centered Roguelite Chaos

Mewgenics blends base-building cat breeding with tactical, turn-based dungeon combat across interconnected acts, rewarding experimentation with hybrid classes and mutations while delivering irreverent humor and a distinctive Isaac-inspired aesthetic; the depth is staggering and highly addictive, though newcomers may feel overwhelmed by its systems, limited early information on breeding and items, and the sheer randomness that can both empower and derail runs.

via GameSpot|
#cat-breeding#gaming#mewgenics
AlphaGenome: DeepMind’s AI Maps the Genome’s Hidden Rules
science28 days ago

AlphaGenome: DeepMind’s AI Maps the Genome’s Hidden Rules

DeepMind’s AlphaGenome trains an AI on vast molecular data to forecast how mutations and regulatory DNA elements alter gene activity, extending the AlphaFold-era breakthrough from proteins to the genome; experts see it as a major engineering advance with potential for cancer and disease research, but stress it remains a predictive tool—its scope is limited to single mutations in a given genome, its predictions don’t capture all splice-site complexities, and clinical use still requires lab validation.

via The New York Times|
#artificial-intelligence#dna#gene-regulation
Older Men's Sperm Have More Mutations, Potentially Harmful
science4 months ago

Older Men's Sperm Have More Mutations, Potentially Harmful

Research shows that as men age, their sperm accumulate more mutations, some of which are harmful and linked to developmental disorders and cancers, increasing the potential health risks for their children. The study highlights the role of 'selfish' mutations that outcompete others in the testes, with mutation rates rising from 2% in men in their 30s to about 4.5% in men over 70, though not all mutations are necessarily passed on or harmful. Further research is needed to understand the full impact on offspring health.

via ScienceAlert|
#aging#disease-risk#genetics
Canadian Teen's Bird Flu Case Sparks Mutation Concerns
health1 year ago

Canadian Teen's Bird Flu Case Sparks Mutation Concerns

The H5N1 avian influenza virus is slowly spreading among mammals and has been detected in wastewater in Texas, raising concerns about its potential to cause a pandemic. A Canadian teenager recently fell critically ill with a mutated strain of the virus, highlighting its ability to infect humans. Public health experts advise stockpiling masks and supplies, practicing good hygiene, and staying informed through reliable news sources. The situation underscores the importance of preparedness and vigilance in the face of potential viral outbreaks.

via Daily Kos|
#avian-influenza#h5n1#health
Canadian Teen's Critical Bird Flu Case Highlights Mutation Risks
health1 year ago

Canadian Teen's Critical Bird Flu Case Highlights Mutation Risks

A Canadian teenager infected with the H5N1 bird flu virus has shown mutations that could potentially make the virus more capable of infecting humans, though there is no evidence of human-to-human transmission. The mutations were identified in the virus's hemagglutinin protein, which is crucial for cell attachment. While the teenager remains in critical condition, the case highlights the potential pandemic risk if the virus acquires the ability to spread easily among humans. Scientists emphasize the need for increased surveillance and monitoring of such mutations.

via STAT|
#bird-flu#canada#h5n1
Unlocking Ancient Tree Secrets: Clonal Mutation Insights
science1 year ago

Unlocking Ancient Tree Secrets: Clonal Mutation Insights

A team of researchers has sequenced the Pando aspen, one of the world's oldest trees, to study mutations in clonally reproducing organisms. The Pando aspen, a triploid species that reproduces by cloning, occupies 42.6 hectares in Utah's Fishlake National Forest and is estimated to be between 16,000 and 80,000 years old. The study identified approximately 4,000 genetic variants in the tree, highlighting its unique evolutionary traits, such as larger cells and enhanced fitness, which contribute to its longevity.

via Phys.org|
#clonal-reproduction#evolution#genetics
Genomic 'Butterfly Effect' and Autism: Unraveling the Genetic Connection
science2 years ago

Genomic 'Butterfly Effect' and Autism: Unraveling the Genetic Connection

A new study suggests that mutations in regulatory regions of DNA, known as promoters, can influence the expression of autism-related genes elsewhere in the genome through a complex mechanism called the "butterfly effect." These mutations, even if unrelated to autism, can impact the activity of genes tied to the disorder, potentially leading to an increased risk of autism spectrum disorder (ASD). The study, which analyzed the genomes of over 5,000 people with autism, found a direct association between autism and gene regulatory mechanisms within specific 3D configurations of the genome called topologically associated domains (TADs). The findings could have potential therapeutic implications for ASD, as they may lead to the development of treatments that modulate the activity of specific promoters to regulate multiple autism-linked genes simultaneously.

via Livescience.com|
#autism#dna#gene-expression
health2 years ago

"Unraveling the JN.1 COVID Variant: Symptoms, Concerns, and What You Need to Know"

Israel has identified a new COVID-19 variant, JN.1, which has affected around 200 people and is a distant descendant of the Omicron family. This variant is more complex, potentially resistant to natural defenses and existing vaccines, and has different symptoms, including a runny nose, cough, headache, and fatigue. While existing vaccines may offer some protection, they are not comprehensive, but manufacturers are working on updates. The high mutation rate of coronaviruses suggests that new strains will continue to emerge, making high vaccination rates crucial. The Israeli Health Ministry advises the public, especially high-risk individuals, to get vaccinated and receive the flu vaccine.

via The Jerusalem Post|
#covid-19#health#israel
"Global Concerns Rise as Highly Mutated COVID Variant 'Pirola' Spawns and Death Toll Mounts"
health-covid-192 years ago

"Global Concerns Rise as Highly Mutated COVID Variant 'Pirola' Spawns and Death Toll Mounts"

The World Health Organization reported nearly 10,000 global COVID-19 deaths in December, with a surge in highly mutated variant "Pirola" JN.1 and its offspring, including JN.1.4, climbing the charts in the U.S. and globally. The variant is linked to increased hospitalizations and ICU admissions, with concerns about its potential to spawn more relatives. Experts warn that the pandemic's trajectory depends on mitigation efforts and the virus's ability to find new hosts.

via Fortune|
#covid-19#global-death-toll#health-covid-19