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Salt cycles drive mixed clonal-aggregative multicellularity in a choanoflagellate
23 minutes ago•Source: Nature
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Pre-ZGA 3D genome architecture emerges modularly in Drosophila embryos
Using Pico-C, a low-input Micro-C method, the study maps high-resolution 3D genome architecture across NC9–NC14 in early Drosophila embryos and reveals that chromatin loops and boundaries emerge in an ordered, modular fashion before major ZGA. Transcriptional elongation inhibition preserves some early loops but weakens promoter insulation, while sequence-based models show orthogonal motif-driven contributions to architecture. Co-depleting Zelda and GAF confirms locus-specific regulatory inputs, supporting a layered regulatory logic for genome establishment prior to ZGA.
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Widespread Presence of Persistent Lytic Phages in Bacterial Genomes
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Widespread Gene Sweeps in Human Gut Microbiomes
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Revealing the Ancient Origins and Evolution of Complex Life on Earth
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Genomic convergence drove the rise of land animals
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