Nobel laureate Venki Ramakrishnan discusses the burgeoning field of ageing science, noting significant scientific advancements but cautioning that practical treatments are still in development. His new book, 'Why We Die,' highlights the explosion of research and investment in the field, with the anti-ageing market projected to grow significantly by 2030. Despite the hype, Ramakrishnan emphasizes that translating research into real-life applications remains a work in progress.
Valter Longo, a gerontology professor, aims to live to 120 and believes his fasting-mimicking diet (FMD) is key. FMD involves a short-term, low-calorie diet mimicking fasting for 15 days per year, with 12-hour fasting and feeding periods on non-FMD days. Research suggests FMD may reduce aging markers, but caution is advised. Longo also advocates a modified Mediterranean diet rich in vegetables, lean proteins, and varied fish, emphasizing the importance of avoiding ultra-processed foods, staying active, and getting enough sleep to live longer.
A recent study has revealed that cell membrane damage can lead to cellular senescence, a state associated with aging and disease, adding a third possible outcome to the previously understood consequences of cell damage. This discovery opens new paths for promoting healthy aging by understanding and manipulating the underlying mechanisms of cellular senescence, shedding light on the impact of moderate membrane damage on cell fate and potential strategies for achieving healthy longevity in the future.
Longevity researchers are focusing on increasing the number of disease-free years, known as health span, as people are living longer but spending more time dealing with health conditions. Genetic studies of centenarians are providing insights into health-promoting genes, with a focus on mimicking their effects through drugs. Lifestyle factors such as diet, exercise, social engagement, and good sleep are also crucial for improving health span. Some researchers are experimenting with off-label medications to combat aging, but the long-term effects are unknown. Better self-monitoring and social connectivity are also emphasized as key pillars for expanding health span.
