All articles tagged with #gut microbiota
Research shows that maternal consumption of common food additives called emulsifiers can negatively impact the gut microbiota of offspring, leading to increased risks of inflammatory bowel conditions and obesity later in life, highlighting the need for further human studies and regulation of food additives in products like baby formula.
A Brazilian cohort study suggests that high consumption of non-caloric artificial sweeteners may be associated with accelerated cognitive decline over eight years, raising concerns about their long-term safety despite regulatory approval, with potential mechanisms involving neurotoxicity and gut microbiota alterations.
A study found common and distinct patterns in gut bacteria among children with autism, ADHD, and anorexia nervosa, revealing links between gut microbes, appetite hormones, and brain health, though further research is needed due to limitations like small sample size.
Researchers in Spain found a link between the amino acid proline, found in foods like beef and fish, and depression, suggesting that controlling proline levels or its transport to the brain could help prevent or treat depression, with gut bacteria playing a significant role in this process.
The SWEET study is a 1-year randomized controlled trial that found replacing sugar with sweeteners and sweetness enhancers in a healthy, sugar-reduced diet improved weight loss maintenance and altered gut microbiota composition in adults with overweight or obesity, without adverse effects on cardiometabolic health markers.
Researchers discovered that a constipation drug, lubiprostone, can slow kidney function decline in CKD patients by improving gut microbiota and mitochondrial health, showing promise as a new treatment approach.
A Phase II clinical trial led by Tohoku University found that lubiprostone, a drug typically used for constipation, can help prevent the decline of kidney function in CKD patients by improving gut microbiota and mitochondrial function, offering a potential new treatment approach.
Researchers found that gut microbes and immune responses significantly influence autism-like behaviors in mice, with probiotics like L. reuteri IMB015 showing potential as a treatment by restoring neurotransmitter balance and reducing inflammation.
A newly isolated gut bacterium, YB328, enhances the effectiveness of PD-1 blockade immunotherapy by promoting dendritic cell migration and activating T cells, leading to improved cancer treatment responses across various tumor types, as demonstrated in patient samples and mouse models.
A new study suggests that gut bacteria may play a causal role in the development of OCD, identifying specific bacteria linked to increased or decreased risk, which could lead to novel treatment strategies in the future.
New research warns that fecal microbiota transplants (FMT) can cause long-lasting mismatches in gut regions, leading to metabolic and behavioral changes, and proposes omni-microbial transplants to better match microbes with their native gut environments.
A small study found that walnut consumption in adults with obesity improved gut microbiota, reduced gut permeability, and enhanced insulin response, suggesting potential benefits for metabolic health. The study involved controlled dietary interventions with walnuts, walnut oil, and corn oil, showing specific microbial and metabolic changes associated with walnut intake.
A study by Northwestern University suggests that gut microbes may have played a crucial role in the evolution of larger brains in primates by influencing energy production and usage. Researchers found that gut microbes from larger-brained primates like humans and squirrel monkeys enhanced energy production in mice, while those from smaller-brained primates like macaques favored fat storage. This indicates that gut microbiota differences evolved to meet the higher energy demands of larger brains, offering new insights into human evolution and the role of gut microbes in shaping metabolic traits.
A recent clinical trial has shown that fecal microbiota transplants (FMTs) from healthy donors into early stage Parkinson's patients led to mild but significant improvement in motoric symptoms over the course of a year, suggesting a potential new treatment for Parkinson's disease. The research team from Belgium administered the fecal transplants through the noses of the patients, with participants showing improvements in motor scores and slower development of constipation. While more research is needed, this study offers promising hints that FMT could be a valuable new treatment for Parkinson's disease, potentially leading to the development of a bacterial pill or other targeted therapy in the future.
Five scientists at the Institut Pasteur discussed the complexity and significance of the gut microbiota, emphasizing its impact on general health and its potential applications in medical treatments. The microbiota, consisting of a vast community of microorganisms, plays a crucial role in various bodily functions and has been linked to conditions such as inflammatory bowel disease, diabetes, obesity, arthritis, and mental health disorders. Research has revealed the beneficial effects of the microbiota on the immune system, brain function, and addiction, leading to potential therapeutic interventions such as fecal microbiota transplantation for treating certain medical conditions.