Autoimmune Mechanisms in ALS Reveal New Disease Insights
TL;DR Summary
The study identifies C9orf72 as a major autoantigen targeted by CD4+ T cells in ALS patients, with responses skewed towards an anti-inflammatory profile, especially in those with longer survival, suggesting a potential protective immune component in ALS progression.
- Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis Nature
- ALS Breakthrough Shows Fatal Disease Is Driven by Immune Attack Bloomberg.com
- ALS appears to be an autoimmune disease La Jolla Institute for Immunology
- Immune checkpoints may predict ALS severity, progression ALS News Today
- Autoimmune responses found in ALS, pointing to a new way to view the deadly disease statnews.com
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