GLP-1 Medications Surge in Pregnancy Amid Sparse Safety Data
TriNetX analysis (2019–2024) shows predelivery GLP-1 receptor agonist use rising from 0.2 to 6.4 per 1000 deliveries and postdelivery use from 0.3 to 14.6 per 1000. In 2024, recipients commonly had obesity and anxiety or mood disorders, with gestational diabetes also noted. Semaglutide and tirzepatide were studied. Data are aggregate with limited safety information, prompting clinicians to consider nutritional status and perinatal psychosocial histories in care.













