All articles tagged with #testosterone
A Michigan State University study shows IL-10–producing monocytes actively resolve inflammatory pain; higher testosterone in males boosts these cells, leading to faster pain relief, while females’ monocytes are less active and pain persists longer. This immune-driven mechanism suggests non-opioid treatments that enhance IL-10 signaling could prevent chronic pain.
A new Science Immunology study of 245 people with traumatic injuries, plus mouse experiments, suggests women’s pain lasts longer because their immune system is less effective at shutting off pain; men have higher interleukin-10, and testosterone boosts interleukin-10 production, helping pain fade faster. The findings, which align with observed sex differences in chronic pain, could guide future treatments (including hormone-based options) while acknowledging that pain biology is not explained by a single pathway.
Neuroscientist Andrew Huberman disclosed he has been on low-dose testosterone replacement therapy (about 125 mg per week) since age 45, a revelation that clashes with his science-backed, supplement-promotion persona and has sparked fan backlash accusing him of misleading followers. Some fans aren’t surprised given past hints, while others see it as hypocrisy amid his broader health lab-style branding and recent CBS News contributor role.
Doctors are increasingly acknowledging irritable male syndrome as a real effect of midlife testosterone decline in men, with symptoms like mood changes, low motivation, fatigue, sleep disturbances, reduced libido, and physical changes. While not yet a formal diagnosis, experts compare it to menopause-like hormonal shifts in women and stress the need for more research and careful treatment decisions, including the careful use of testosterone therapy after medical screening.
A study of 104 Shuar men in Amazonian Ecuador finds that Western notions of a single “normal” testosterone pattern don’t apply globally. Morning testosterone levels were lower than in the US and declined across the day, with age and body fat producing different lifespan patterns: lean men show an inverted U with a midlife peak, while higher-fat men peak earlier and then decline. Social factors also matter, as men with partners had lower morning levels. The results challenge universal clinical benchmarks and highlight energy, environment, and lifestyle as drivers of hormonal regulation, though the cross-sectional design limits causal conclusions.
A study of 46 popular posts across TikTok and Instagram with millions of followers finds ‘manosphere’-aligned influencers promoting routine testosterone testing and treatments to healthy young men, framing normal variations in energy or mood as evidence of deficiency. The research links this marketing to broader cultural narratives about masculinity and notes many posts conceal financial ties to products. Experts say routine screening for low testosterone in asymptomatic young men is not supported by guidelines, and a single test cannot diagnose a condition given hormonal fluctuations and the need for medical context.
Mohammed Usman accepted a 30-month suspension after testing positive for testosterone before UFC Rio 2025 against Valter Walker and for earlier use, plus a banned peptide. He admitted testosterone use and attempted to deceive CSAD with a false explanation; aggravating factors led to an extra six months added to the standard two-year ban, with the sentence ending April 9, 2028.
Combat Sports Anti-Doping (CSAD) announced Mohammed Usman accepted a 2-year and 6-month suspension under the UFC Anti-Doping Policy for testosterone use, with aggravating factors adding six months; the ban runs from Oct. 9, 2025, to Apr. 9, 2028. Usman had previously been pulled from a Rio de Janeiro card after a positive test and admitted to testosterone use and BPC-157. UFC ADP testing is conducted by Drug Free Sport International and analyzed at the SMRTL lab; more information is available at ufcantidoping.com.
New dietary guidelines include a section on testosterone health in men, noting that diet may modestly influence testosterone but the evidence is weak; recommendations emphasize healthy fats (avoiding very low-fat diets), potential DHA supplementation, zinc, and vitamin D, while cautioning against excessive protein. Weight loss in overweight men is linked to higher testosterone, though no single food will dramatically boost levels. Experts urge cautious interpretation and more research.
Recent research has challenged the long-held belief that testosterone promotes prostate cancer growth, showing that testosterone therapy is safe for men with low levels and may even help in managing prostate cancer, leading to a shift in medical practice and treatment approaches.
The article discusses the historical decline and recent resurgence of testosterone therapy in medicine, highlighting how misconceptions, particularly linking testosterone to prostate cancer, led to its decline. Abraham Morgentaler played a key role in challenging these beliefs through clinical evidence, showing that testosterone therapy is safe for men with hypogonadism and emphasizing the importance of considering individual patient experiences. The piece also explores the cultural and medical biases that have hindered the acceptance of testosterone treatment.
The article discusses the effects of abstaining from masturbation for a month during No Nut November, highlighting that scientific evidence for claimed benefits like increased testosterone and improved semen quality is limited or questionable. Experts suggest that testosterone levels may only temporarily rise due to anticipation, and prolonged abstinence can actually harm semen quality, making it less beneficial for fertility. The article also notes that abstinence can lead to nocturnal emissions and may help break porn addiction.
A Polish study found that women perceive men with lower body fat as more attractive, and facial masculinity correlates with higher testosterone and age. While initial links between facial appearance and health markers like cardiometabolic health were observed, these were explained by broader factors such as adiposity, age, and testosterone levels, suggesting facial cues reflect overall biological condition rather than specific health issues.
Jason Fox, a 49-year-old former Special Forces soldier, discussed his experience with declining testosterone levels, which measured at 11 nmol/L—below the optimal range—contributing to his fatigue and aches. While age-related testosterone decline is common, some men may have hormonal issues that can be addressed, though testosterone therapy should be considered carefully. The article highlights the natural decrease in testosterone with age and the potential for hormonal treatment.
A longevity expert emphasizes the importance of hormonal health in middle-aged men, highlighting that declining testosterone levels—by 30-50% between ages 30 and 70—can impact sexual function, mood, metabolism, and muscle mass. He recommends men get tested for testosterone levels and suggests lifestyle changes like healthy eating and resistance training to naturally boost testosterone, potentially improving quality of life and long-term health.