All articles tagged with #il 10
New research in mice and humans suggests that immune cells produce IL-10 to help resolve pain, and sex differences in this response—shaped by testosterone—may explain why women often recover more slowly from injury and have a higher risk of chronic pain. These findings point to therapies that boost the body's natural pain-resolution system rather than only blocking pain signals.
A Michigan State University study shows IL-10–producing monocytes actively resolve inflammatory pain; higher testosterone in males boosts these cells, leading to faster pain relief, while females’ monocytes are less active and pain persists longer. This immune-driven mechanism suggests non-opioid treatments that enhance IL-10 signaling could prevent chronic pain.
The study reveals that TCF1 and LEF1 transcription factors are crucial for the maintenance, development, and regulatory function of B-1a cells in mice and humans, promoting IL-10 production and limiting inflammation, with implications for immune regulation and autoimmune diseases.