Jennifer Doudna's startup Aurora Therapeutics aims to scale personalized gene-editing treatments for rare diseases like PKU using CRISPR technology and a new FDA pathway that expedites approval for bespoke therapies based on limited patient data.
Menlo Ventures has invested $16 million in Aurora Therapeutics, co-founded by CRISPR pioneer Jennifer Doudna and Fyodor Urnov, to develop personalized CRISPR therapies targeting rare diseases like PKU, leveraging recent regulatory and technological advances to make treatments for ultra-rare conditions more feasible.
A prominent gene editing researcher from UC Berkeley, Fyodor Urnov, and venture capitalist Johnny Hu are launching a startup to scale personalized CRISPR medicines, aiming to treat ultra-rare genetic mutations and overcome regulatory and commercial challenges.
A comprehensive immune cell atlas from over 400 Chinese individuals reveals significant genetic and functional differences compared to European and Japanese populations, highlighting the importance of diverse data sets for personalized medicine and understanding immune variation across populations.
Researchers have developed mini brain organoids from patient cells that exhibit distinct electrical activity patterns, enabling accurate identification of schizophrenia and bipolar disorder, which could lead to improved diagnosis and personalized treatment options.
Siddhartha Mukherjee advocates for treating metabolism as a primary target in cancer therapy, emphasizing tumor-informed dietary interventions combined with drugs to improve outcomes and prevent resistance, moving towards precision nutrition as a complement to pharmacology.
A study from Intermountain Health shows that personalized, monitored vitamin D3 supplementation after a heart attack can reduce the risk of a second attack by 50%, emphasizing the importance of targeted treatment to achieve optimal blood levels of vitamin D.
Vitamin D deficiency is linked to increased heart disease risk, and personalized supplementation guided by regular blood testing can significantly reduce recurrent heart attacks, emphasizing the importance of tailored approaches over standard dosing for optimal cardiovascular health.
A woman with advanced ovarian cancer was saved by identifying her rare genetic condition, Lynch syndrome, through molecular testing, which led to effective immunotherapy treatment and a significant remission, highlighting the importance of genetic diagnosis in cancer treatment.
A study analyzing real-world data suggests that the new schizophrenia drug Cobenfy is most effective for patients with negative symptoms like social withdrawal, supporting the move toward precision psychiatry by identifying biological subtypes of psychosis that respond differently to treatment.
California cardiologist Dr. Bhojraj emphasizes that protecting heart health doesn't require cutting out all 'bad' foods or relying on numerous supplements and quick fixes. Instead, understanding your body's signals and addressing root causes like inflammation, hormones, and stress through personalized diagnostics and medicine is key to maintaining vitality and preventing heart issues.
A comprehensive study published in The Lancet highlights that antidepressants can cause significant physical changes such as weight gain, blood pressure, and heart rate variations, emphasizing the need for personalized treatment plans and shared decision-making between doctors and patients.
New research reveals that exercise rewires the body at a molecular level, influencing biological pathways and potentially serving as a powerful form of preventive medicine for chronic diseases, with future prospects for personalized exercise therapies based on molecular biomarkers.
A study published in Nature Medicine reveals that hormone replacement therapy (HRT) for trans women causes biological changes at the molecular level, aligning their protein biomarkers more closely with cisgender women, and potentially improving immune and heart health. The research underscores the biological malleability of adults and suggests a need for personalized HRT monitoring to optimize health outcomes.
A comprehensive analysis of 30 antidepressants reveals significant differences in their physical side-effects, emphasizing the importance of personalized prescribing based on individual health profiles and preferences, supported by a new decision-making tool for doctors and patients.