Tag

Cancer Vaccine

All articles tagged with #cancer vaccine

health-and-medicine25 days ago•6 min saved

CD27 boost could unlock long-lasting cancer vaccine immunity

A 20-year-old breast cancer vaccine trial shows all participants are still alive decades later, suggesting durable immune memory. Researchers found persistent CD27-marked CD4+ T cells can recognize the cancer, hinting that CD27 could make cancer vaccines more effective. In mice, combining the vaccine with a CD27-activating antibody nearly doubled tumor elimination (about 40% complete responses vs 6% with vaccine alone); adding extra support for CD8+ T cells pushed tumor rejection to ~90%. These findings imply CD27 could be a key addition to cancer vaccines and compatible with existing therapies.

via ScienceDaily|

#cancer-vaccine #cd27 #cd4-t-cells

science1 month ago•7 min saved

Decades-Old Breast Cancer Vaccine Triggers Durable Immune Memory, New Boosting Approach Emerges

Researchers studied survivors from a decades-old breast cancer vaccine trial and found they retain powerful CD27+ immune memory years later. In mice, combining a CD27-activating antibody with a HER2-targeting vaccine dramatically increased tumor rejection, largely via CD4+ T cells and, with additional CD8+ T-cell support, boosted efficacy to near 90%. The findings suggest CD4+ T cells can drive lasting anti-tumor immunity and that a single CD27 boost alongside vaccines could enhance cancer immunotherapies in humans.

via SciTechDaily|

#cancer-vaccine #cd27 #cd4-t-cells

health1 month ago•8 min saved

Personalized Melanoma Vaccine Shows Strong, Lasting Benefit with Immunotherapy

Moderna and Merck report promising results for a patient-tailored mRNA cancer vaccine paired with Keytruda in high-risk melanoma. The vaccine, designed from a patient’s tumor mutations (neoantigens), reduced recurrence or death by 49% versus immunotherapy alone and demonstrated durable immune memory over five years, signaling a potential breakthrough for personalized cancer vaccines and future skin-cancer prevention.

via ZME Science|

#cancer-vaccine #health #immunotherapy

markets1 month ago•15 min saved

Moderna Surges 10% on Positive Melanoma Trial Results for Cancer Vaccine

Moderna shares rose about 10% after Phase 2 data showed its cancer vaccine, when combined with Keytruda, reduced relapse or death risk in melanoma, signaling potential for its oncology pipeline as Covid-era vaccine sales fade and cash stockpiles dwindle. Evercore ISI called the asset a key value driver, while the stock remains rated a Hold by analysts with notable downside risk baked into targets.

via TipRanks|

#cancer-vaccine #keytruda #markets

health1 month ago•4 min saved

Personalized mRNA melanoma vaccine trims five-year recurrence risk by almost 50%, Moderna and Merck report

In a Phase 2 trial of 157 high‑risk stage 3/4 melanoma patients, Moderna and Merck’s personalized mRNA vaccine (mRNA-4157) plus Keytruda reduced recurrence or death at five years by about 49% versus Keytruda alone. Earlier two- and three-year data showed similar risk reductions (44% and 49%). Safety was similar between groups, with fatigue, injection-site pain, and chills most common. Full data aren’t yet published; a Phase 3 trial is underway and more data from this program are expected.

via Ars Technica|

#cancer-vaccine #health #immunotherapy

health1 month ago•6 min saved

Preventive Cancer Vaccine Sparks Hope for Lynch Syndrome Carriers in Early Trial

A phase 1b/2 trial of a preventive cancer vaccine for Lynch syndrome carriers, including Kevin Heyink, showed the vaccine is safe and elicits a lasting immune response. In a 45-participant trial, vaccinated individuals had fewer precancerous lesions and no advanced tumors; Heyink has since had three cancer-free colonoscopies in a row. The vaccine uses a modified adenovirus to train the immune system to recognize Lynch-related proteins, offering hopeful potential to reduce cancer risk, though larger trials are needed before wider use.

via TODAY.com|

#cancer-vaccine #clinical-trial #health

health2 months ago•5 min saved

Scientists Near Breakthrough in Universal Cancer Vaccine

Scientists at UMass Amherst have developed a nanoparticle-based vaccine that successfully prevents multiple aggressive cancers in mice, including melanoma, pancreatic, and breast cancers, by activating strong immune memory and targeting cancer-specific antigens, with potential for broad application in cancer prevention and treatment.

via SciTechDaily|

#cancer-vaccine #health #immunotherapy

health3 months ago•3 min saved

Old Cancer Vaccine Shows Promise for Breast Cancer Survival

A study of women treated over 20 years ago with a cancer vaccine shows long-lasting immune responses, and researchers found that targeting the CD27 marker could enhance vaccine effectiveness, potentially improving long-term survival in breast cancer patients.

via Medical Xpress|

#breast-cancer #cancer-vaccine #health

health4 months ago•2 min saved

Innovative Cancer Vaccine Shows Promising Long-Term Prevention in Mice

A new nanoparticle-based cancer vaccine shows promising results in mice, preventing multiple tumor types with up to 88% efficacy over 250 days, though human applicability remains to be tested.

via ScienceAlert|

#cancer-vaccine #health #immunotherapy

health6 months ago•3 min saved

Universal Cancer Vaccine Effectively Eliminates Resistant Tumors in Mice

Researchers at the University of Florida have developed a promising universal cancer vaccine using mRNA technology that stimulates the immune system to attack various tumors, especially when combined with immune checkpoint inhibitors, showing strong results in mice and paving the way for future human trials.

via ScienceAlert|

#cancer-vaccine #clinical-trials #health

health6 months ago•3 min saved

Controversy and Concerns Surrounding mRNA Vaccine Developments in America

RFK Jr. has canceled promising research on a cancer vaccine due to his anti-vaccine stance, risking the US's leadership in mRNA technology, which is crucial for rapid response to health threats and national security, and potentially ceding this strategic advantage to countries like China.

via Futurism|

#biomedical-arms-race #cancer-vaccine #health

health6 months ago•1 min saved

Emerging Technologies and Trends Transforming Healthcare in 2025

The article highlights three key innovations in medical technology: a cancer vaccine, an Alzheimer's blood test, and a life-changing exoskeleton, emphasizing their potential to advance healthcare and economic prosperity.

via NPR|

#alzheimers-blood-test #cancer-vaccine #exoskeleton

health6 months ago•2 min saved

Promising Off-the-Shelf Cancer Vaccine Extends Survival and Prevents Recurrence

An experimental off-the-shelf cancer vaccine called ELI-002 shows promising early results in prolonging survival and inducing immune responses in patients with pancreatic and colorectal cancers harboring KRAS mutations, with further trials underway to confirm its efficacy.

via Gizmodo|

#cancer-vaccine #colorectal-cancer #eli-002

health6 months ago•3 min saved

Promising Advances in Vaccines and Signs for Pancreatic Cancer

A non-personalized off-the-shelf vaccine called ELI-002 2P shows promise in preventing the return of pancreatic and colorectal cancers by training the immune system to target specific mutations, with early results indicating longer survival for responders, though further research is needed.

via The Guardian|

#cancer-vaccine #colorectal-cancer #eli-002-2p

health7 months ago•5 min saved

Promising Advances in Universal Cancer Vaccine Development

A new universal mRNA-based cancer vaccine shows promise in animal studies by boosting the immune system's innate response, particularly type-I interferons, and enhancing existing therapies like immune checkpoint inhibitors. Researchers are now testing a combined off-the-shelf and personalized vaccine approach in human trials for recurrent cancers, aiming to provide rapid, broad-spectrum cancer treatment.

via Live Science|

#cancer-treatment #cancer-vaccine #clinical-trials