All articles tagged with #neuroinflammation
Research suggests that high levels of the oral bacterium Fusobacterium nucleatum may be linked to increased disability in multiple sclerosis patients, indicating a possible MS-specific oral–brain inflammatory pathway and highlighting the importance of oral health in disease progression.
Scientists from Northwestern University developed a promising drug called NU-9 that effectively stalls Alzheimer's in mouse models by reducing toxic amyloid beta oligomers and calming brain support cells, potentially enabling early preventative treatment before symptoms appear.
A natural experiment in Wales found that a routine shingles vaccine given to 79-year-olds was associated with a 20% reduction in dementia risk, suggesting that the vaccine may have protective effects on brain health by reducing viral reactivation and neuroinflammation, with potential therapeutic benefits even for those already with dementia.
This study used molecular profiling and innovative proteomics techniques to explore how brain endothelial cells communicate with astrocyte endfeet in mice and humans, revealing dynamic ligand-receptor interactions that are modulated during peripheral inflammation and are conserved across species, with implications for understanding neuroinflammatory and neurodegenerative diseases.
Scientists discovered that people with multiple sclerosis have an imbalanced oral microbiome characterized by a loss of beneficial bacteria and lower levels of the protective metabolite hypotaurine, suggesting that oral bacteria may influence immune dysregulation in MS. These findings could lead to saliva-based diagnostic tools and new treatments aimed at restoring healthy oral bacteria to support neurological health.
Researchers discovered a rare brain cell type called DARGs that are highly prevalent in progressive MS, contribute to chronic inflammation and neurodegeneration by releasing inflammatory signals, and could be targeted for new treatments to slow or halt disease progression.
A study using ultra-high-resolution 7T MRI scanners found that severe Covid-19 can cause lasting damage and inflammation in the brainstem, which may explain long-term physical and psychiatric symptoms such as fatigue, breathlessness, and anxiety, highlighting the importance of brain health in Covid-19 recovery.
Researchers from FIU discovered that elevated levels of the brain protein TSPO in mice and human tissue could serve as an early biomarker for Alzheimer's disease, potentially allowing for diagnosis years before symptoms appear and enabling earlier intervention.
A natural compound called DMT, found in the human brain, shows potential in reducing stroke damage by protecting the blood-brain barrier and decreasing inflammation, with ongoing clinical trials exploring its therapeutic use.
Research indicates that DMT, a natural psychoactive compound, can protect the brain after stroke by restoring blood-brain barrier integrity and reducing inflammation, suggesting its potential as an adjuvant treatment to improve recovery outcomes.
Recent research suggests that adaptive immune cells like T and B cells play a complex role in Alzheimer's disease, sometimes worsening and sometimes protecting against brain damage. This new understanding highlights the potential for therapies that rebalance immune responses, moving beyond traditional focus on protein plaques and tangles to include immune system modulation for more effective treatment options.
Purdue University researchers have discovered that excess fat in brain immune cells impairs their ability to fight Alzheimer's disease, revealing a new lipid-based mechanism involving the enzyme DGAT2. Targeting this enzyme to reduce fat accumulation in microglia restores their function and offers a promising therapeutic approach for neurodegeneration.
Researchers found that gut microbes and immune responses significantly influence autism-like behaviors in mice, with probiotics like L. reuteri IMB015 showing potential as a treatment by restoring neurotransmitter balance and reducing inflammation.
Childhood trauma causes lasting changes in the brain and immune system through neuroinflammation, increasing the risk of psychiatric disorders later in life. New research by Dr. Sara Poletti highlights the potential for early detection and targeted interventions using biological markers, emphasizing the importance of trauma-informed policies and preventive strategies.
New research indicates that aging brains are more vulnerable to even mild oxygen deprivation, leading to increased blood-brain barrier disruption and inflammation, which may contribute to neurodegeneration and cognitive decline, especially in individuals with chronic respiratory or cardiovascular conditions.