Tag

Neuroinflammation

All articles tagged with #neuroinflammation

science6 days ago•25 min saved

Caffeine Linked to Reduced Brain Inflammation and Mood Benefits in Rodent Studies

A systematic review of 17 rodent experiments finds caffeine consistently lowers brain inflammation and improves anxiety- and depression-like behaviors, likely via adenosine receptor blockade, increased brain-derived neurotrophic factor, and reduced pro-inflammatory cytokines and oxidative stress; caffeine's effects are comparable to some antidepressants in animals, but most data come from adult male rodents with varied dosing, so human studies are needed to determine safety and applicability.

via PsyPost|

#anxiety #caffeine #depression

health28 days ago•265 min saved

THC and celecoxib combo slows Alzheimer's-like brain changes in mice

In two mouse models of Alzheimer's disease, researchers found that very low-dose THC improved memory and reduced brain inflammation, and when combined with celecoxib (a COX-2 inhibitor anti-inflammatory) it led to even stronger benefits, including reduced beta-amyloid plaques and tau tangles and healthier gene activity. THC alone offered limited benefits and increased inflammation; the combo reversed that trend and showed greater cognitive improvement. With both drugs already approved for other uses, the team hopes to move toward human trials to see if the benefits translate to slowing or reversing disease progression.

via AOL.com|

#alzheimers-disease #celecoxib #health

science1 month ago•5 min saved

Alzheimer’s breakthrough: a single brain receptor triggers synapse erasure

Researchers identify LilrB2 as a shared receptor that Reacts to amyloid beta and the inflammatory fragment C4d to trigger neurons to prune their own synapses, linking two major Alzheimer's theories. This neuron-autonomous mechanism suggests therapies should aim to protect synapses rather than solely dismantle plaques to preserve memory.

via Indian Defence Review|

#alzheimers-disease #amyloid-beta #lilrb2

health2 months ago•6 min saved

Oral Bacteria Linked to Increased Disability in Multiple Sclerosis Patients

Research suggests that high levels of the oral bacterium Fusobacterium nucleatum may be linked to increased disability in multiple sclerosis patients, indicating a possible MS-specific oral–brain inflammatory pathway and highlighting the importance of oral health in disease progression.

via Neuroscience News|

#fusobacterium-nucleatum #health #multiple-sclerosis

health2 months ago•3 min saved

New Drug Shows Promise in Early Alzheimer's Prevention and Treatment

Scientists from Northwestern University developed a promising drug called NU-9 that effectively stalls Alzheimer's in mouse models by reducing toxic amyloid beta oligomers and calming brain support cells, potentially enabling early preventative treatment before symptoms appear.

via ScienceAlert|

#alzheimers #amyloid-beta-oligomers #early-detection

health2 months ago•4 min saved

Shingles Vaccine May Reduce Dementia Risk and Progression

A natural experiment in Wales found that a routine shingles vaccine given to 79-year-olds was associated with a 20% reduction in dementia risk, suggesting that the vaccine may have protective effects on brain health by reducing viral reactivation and neuroinflammation, with potential therapeutic benefits even for those already with dementia.

via Earth.com|

#dementia #health #neuroinflammation

neuroscience3 months ago•95 min saved

Molecular Insights into Brain Endothelial-Astrocyte Communication in Mice and Humans

This study used molecular profiling and innovative proteomics techniques to explore how brain endothelial cells communicate with astrocyte endfeet in mice and humans, revealing dynamic ligand-receptor interactions that are modulated during peripheral inflammation and are conserved across species, with implications for understanding neuroinflammatory and neurodegenerative diseases.

via Nature|

#astrocyte-endfeet #blood-brain-barrier #brain-endothelial-cells

health4 months ago•7 min saved

Distinct Oral Microbiome Linked to Multiple Sclerosis

Scientists discovered that people with multiple sclerosis have an imbalanced oral microbiome characterized by a loss of beneficial bacteria and lower levels of the protective metabolite hypotaurine, suggesting that oral bacteria may influence immune dysregulation in MS. These findings could lead to saliva-based diagnostic tools and new treatments aimed at restoring healthy oral bacteria to support neurological health.

via Neuroscience News|

#health #microbiome-dysbiosis #multiple-sclerosis

health-and-science4 months ago•6 min saved

Researchers Identify Inflammatory Brain Cells as Key in Progressive MS

Researchers discovered a rare brain cell type called DARGs that are highly prevalent in progressive MS, contribute to chronic inflammation and neurodegeneration by releasing inflammatory signals, and could be targeted for new treatments to slow or halt disease progression.

via Neuroscience News|

#darg-cells #health-and-science #multiple-sclerosis

health4 months ago•4 min saved

New Research Identifies Brainstem Damage as Cause of Long COVID Brain Fog

A study using ultra-high-resolution 7T MRI scanners found that severe Covid-19 can cause lasting damage and inflammation in the brainstem, which may explain long-term physical and psychiatric symptoms such as fatigue, breathlessness, and anxiety, highlighting the importance of brain health in Covid-19 recovery.

via News-Medical|

#brainstem-damage #covid-19 #health

health4 months ago•2 min saved

Brain Signal Could Predict Alzheimer's Years Before Onset

Researchers from FIU discovered that elevated levels of the brain protein TSPO in mice and human tissue could serve as an early biomarker for Alzheimer's disease, potentially allowing for diagnosis years before symptoms appear and enabling earlier intervention.

via ScienceAlert|

#alzheimers #brain-protein #early-detection

health5 months ago•2 min saved

DMT and Natural Compounds Show Promise in Protecting the Brain Post-Stroke

A natural compound called DMT, found in the human brain, shows potential in reducing stroke damage by protecting the blood-brain barrier and decreasing inflammation, with ongoing clinical trials exploring its therapeutic use.

via SciTechDaily|

#blood-brain-barrier #dmt #health

health5 months ago•3 min saved

DMT: A Natural Compound Offering Brain Protection Post-Stroke

Research indicates that DMT, a natural psychoactive compound, can protect the brain after stroke by restoring blood-brain barrier integrity and reducing inflammation, suggesting its potential as an adjuvant treatment to improve recovery outcomes.

via Neuroscience News|

#blood-brain-barrier #dmt #health

health5 months ago•5 min saved

Focus Shifts to Immune System Balance in Alzheimer’s Research

Recent research suggests that adaptive immune cells like T and B cells play a complex role in Alzheimer's disease, sometimes worsening and sometimes protecting against brain damage. This new understanding highlights the potential for therapies that rebalance immune responses, moving beyond traditional focus on protein plaques and tangles to include immune system modulation for more effective treatment options.

via Neuroscience News|

#alzheimers-disease #b-cells #health

health5 months ago•6 min saved

Fat Impairs Brain's Immune Defense in Alzheimer's

Purdue University researchers have discovered that excess fat in brain immune cells impairs their ability to fight Alzheimer's disease, revealing a new lipid-based mechanism involving the enzyme DGAT2. Targeting this enzyme to reduce fat accumulation in microglia restores their function and offers a promising therapeutic approach for neurodegeneration.

via Medical Xpress|

#alzheimers-disease #dgat2-enzyme #health